Ryan, Joanne, Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra, Kildea, Daniel, Henderson, Victor W.

Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women’s Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, […]

Silverman, Daniel H. S., Geist, Cheri L., Kenna, Heather A., Williams, Katherine, Wroolie, Tonita, Powers, Bevin, Brooks, John, Rasgon, Natalie L.

Differential cerebral metabolic effects of various hormone therapy formulations, and their associations with cognitive status, remain to be established. The principal aim of the current study was to assess relationships between regional cerebral metabolism and estrogen-based hormone therapies. Postmenopausal women (n=53) at elevated risk for Alzheimer’s disease (AD) were on estrogen-containing hormone therapy for at […]

Wroolie, T. E., Kenna, H. A., Williams, K. E., Powers, B. N., Holcomb, M., Lazzeroni, L., Rasgon, N. L.

Background: To determine the effects of memantine on cognition in a normal population of postmenopausal women with putative risk factors for Alzheimer’s disease (AD) using a built-in control for the genetic risk factor for AD (apoE-epsilon4 status).; Methods: A prospective, open-label, 6-month pilot medication trial with memantine and follow-up after discontinuance conducted at the Center […]

Villars, Hélène, Dupuy, Charlotte, Soler, Pauline, Gardette, Virginie, Soto, Maria E., Gillette, Sophie, Nourhashemi, Fati, Vellas, Bruno

Background: Emergency room (ER) re-hospitalizations are prevalent in severe Alzheimer’s disease affected older patients. Design: Quasi-experimental before and after study. Setting: Discharge of severely demented patients from a Special Alzheimer Acute Care Unit. Participants: A total of 390 patients hospitalized in the unit from 2007 through 2009, with at least one of the following characteristics: […]

Johansson, C., Ballard, C., Hansson, O., Palmqvist, S., Minthon, L., Aarsland, D., Londos, E.

Objective: This 30-week extension trial was a continuation of the first double-blind randomized controlled trial (RCT) to study memantine in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). The objective was to evaluate the presence of recurrence of symptoms upon drug withdrawal. Furthermore, the aim was to explore washout dynamics in order to […]