Takahashi, Yoshimi, Iseki, Chifumi, Wada, Manabu, Momma, Tadasuke, Ueki, Masao, Kawanami, Toru, Daimon, Makoto, Suzuki, Kyoko, Tamiya, Gen, Kato, Takeo

Objective: Age is known to influence the risk of both cerebral ischemic lesions and impaired cognitive function. Diabetes mellitus (DM) can also be associated with cognitive impairment. However, there has been no study of neuropsychological performance in association with glucose metabolism status and cerebral ischemic lesions in same-aged, community-dwelling elderly persons. The present study was […]

Sink, Kaycee M., Leng, Xiaoyan, Williamson, Jeff, Kritchevsky, Stephen B., Yaffe, Kristine, Kuller, Lewis, Yasar, Sevil, Atkinson, Hal, Robbins, Mike, Psaty, Bruce, Goff, David C.

Background: Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the blood-brain barrier) may protect against dementia beyond HTN control.; Methods: Participants in the Cardiovascular Health Study Cognition Substudy with treated HTN and no diagnosis of congestive heart failure (n = 1054; […]

Reijmer, Yael D., van den Berg, Esther, de Bresser, Jeroen, Kessels, Roy P. C., Kappelle, L. Jaap, Algra, Ale, Biessels, Geert Jan

Background: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes.; Methods: Cognitive functioning and brain volume as well as metabolic and vascular risk factors were assessed twice in […]

Pellfolk, Tony J.-E., Gustafson, Yngve, Bucht, Gösta, Karlsson, Stig

Objectives: To evaluate the effects of a restraint minimization education program on staff knowledge and attitudes and use of physical restraints.; Design: Cluster-randomized controlled trial with nursing units as the basis for randomization.; Setting: Forty group dwelling units for people with dementia.; Participants: At baseline, there were 184 staff and 191 residents in the intervention […]

Miyazawa, Taiki, Nakagawa, Kiyotaka, Takekoshi, Hideo, Higuchi, Ohki, Kato, Shunji, Kondo, Momoko, Kimura, Fumiko, Miyazawa, Teruo

Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact […]

Hyttinen, Laura, TuulioHenriksson, Annamari, Vuorio, Alpo F., Kuosmanen, Noora, Härkänen, Tommi, Koskinen, Seppo, Strandberg, Timo E.

The cognitive status of aged familial hypercholesterolemia (FH) patients treated with long-term statin therapy was compared with that of population controls. A comprehensive cohort of 43 elderly (age > or = 65 years) patients all with the same FH North Karelia mutation living in North Karelia (eastern Finland) was identified, 37 of whom (aged 65 […]