Zuo, Chaoshun, Zuo, Zhiyi

Background: Volatile anesthetics cause Alzheimer’s disease (AD)-like neuropathology in animals. We determined whether spine surgery under general anesthesia and anesthetic choice contributed to AD development.; Methods: We searched the Clinical Data Repository of the University of Virginia for patients receiving spine surgery from January 1, 1992 to March 1, 2004. Patients with newly-diagnosed AD after […]

Stanley, Melinda A., Calleo, Jessica, Bush, Amber L., Wilson, Nancy, Snow, A. Lynn, Kraus-Schuman, Cynthia, Paukert, Amber L., Petersen, Nancy J., Brenes, Gretchen A., Schulz, Paul E., Williams, Susan P., Kunik, Mark E.

Objectives: To assess feasibility and to conduct a preliminary evaluation of outcomes following Peaceful Mind, a cognitive-behavioral therapy-based intervention for anxiety in dementia, relative to usual care. Design: Pilot randomized controlled trial including assessments at baseline and 3 and 6 months. Setting: Houston, TX. Participants: Thirty-two outpatients diagnosed with mild (47%) or moderate (53%) dementia […]

Ng, Tze Pin, Feng, Liang, Yap, Keng Bee, Lee, Tih Shih, Tan, Chay Hoon, Winblad, Bengt

Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective […]

Kiosses, Dimitris N., Ravdin, Lisa D., Gross, James J., Raue, Patrick, Kotbi, Nabil, Alexopoulos, George S.

IMPORTANCE: Problem adaptation therapy (PATH) is a treatment for older adults with major depression, cognitive impairment (from mild cognitive deficits to moderate dementia), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated. OBJECTIVE: To test the efficacy of 12-week PATH vs supportive therapy for cognitively impaired patients (ST-CI) in […]

Kazui, Hiroaki, Mori, Etsuro, Hashimoto, Masaaki, Ishikawa, Masatsune, Hirono, Nobutsugu, Takeda, Masatoshi

Background/aims: Patients with idiopathic normal pressure hydrocephalus (iNPH) are often given shunt operations to reduce the triad symptoms (cognitive impairment, gait disturbance and urinary disturbance). We examined whether they also reduce caregiver burden.; Methods: The personal strain (PS) and role strain (RS) factors, which are related to the stress and constraints, respectively, on the caregivers […]

Husebo, B. S., Ballard, C., Fritze, F., Sandvik, R. K., Aarsland, D.

Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated. Objective: Secondary analyses of a cluster randomized clinical trial […]

Anderson, Craig, Teo, Koon, Gao, Peggy, Arima, Hisatomi, Dans, Antonio, Unger, Thomas, Commerford, Patrick, Dyal, Leanne, Schumacher, Helmut, Pogue, Janice, Paolasso, Ernesto, Holwerda, Nicolaas, Chazova, Irina, Binbrek, Azan, Young, James, Yusuf, Salim

Background: cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials.; Methods: in the main study, ONTARGET, a double-blind, double-dummy, randomised controlled trial, […]