This database contains 542 studies, archived under the term: "middle aged"
Click here to filter this large number of results.
Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial
Gates, Nicola J.,
Valenzuela, Michael,
Sachdev, Perminder S.,
Singh, Nalin A.,
Baune, Bernhard T.,
Brodaty, Henry,
Suo, Chao,
Jain, Nidhi,
Wilson, Guy C.,
Wang, Yi,
Baker, Michael K.,
Williamson, Dominique,
Foroughi, Nasim,
Fiatarone Singh, Maria A.
Background: The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and […]
Memantine for AIDS dementia complex: open-label report of ACTG 301
Zhao, Yu,
Navia, Bradford A.,
Marra, Christina M.,
Singer, Elyse J.,
Chang, Linda,
Berger, Joseph,
Ellis, Ronald J.,
Kolson, Dennis L.,
Simpson, David,
Miller, Eric N.,
Lipton, Stuart A.,
Evans, Scott R.,
Schifitto, Giovanni
Objective: To evaluate the long-term safety and efficacy of memantine use as treatment of HIV-associated cognitive impairment.; Background: The results of a 20-week, randomized, double-blind, placebo-controlled trial of memantine in HIV-infected participants with cognitive impairment (ACTG 301) were previously reported. We report the results of the up-to-60-week open-label phase following the double-blind phase.; Method: Participants […]
MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes
Zhang, Yu,
Tartaglia, Maria Carmela,
Schuff, Norbert,
Chiang, Gloria C.,
Ching, Christopher,
Rosen, Howard J.,
Gorno-Tempini, Maria Luisa,
Miller, Bruce L.,
Weiner, Michael W.
Brain magnetic resonance imaging (MRI) studies have demonstrated regional patterns of brain macrostructural atrophy and white matter microstructural alterations separately in the three major subtypes of frontotemporal lobar degeneration (FTLD), which includes behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). This study was to investigate to what extent the pattern […]
Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease
Zerr, I.,
Kallenberg, K.,
Summers, D. M.,
Romero, C.,
Taratuto, A.,
Heinemann, U.,
Breithaupt, M.,
Varges, D.,
Meissner, B.,
Ladogana, A.,
Schuur, M.,
Haik, S.,
Collins, S. J.,
Jansen, G. H.,
Stokin, G. B.,
Pimentel, J.,
Hewer, E.,
Collie, D.,
Smith, P.,
Roberts, H.,
Brandel, J. P.,
van Duijn, C.,
Pocchiari, M.,
Begue, C.,
Cras, P.,
Will, R. G.,
Sanchez-Juan, P.
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype. In recent years, a series of publications have demonstrated a potentially important role for magnetic resonance imaging in the pre-mortem diagnosis of sporadic Creutzfeldt-Jakob disease. […]
Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]
Adaptive cognitive testing in cerebrovascular disease and vascular dementia
Wouters, Hans,
de Koning, Inge,
Zwinderman, Aeilko H.,
van Gool, Willem A.,
Schmand, Ben,
Buiter, Maarten,
Lindeboom, Robert
Background/aims: To examine whether brevity can be combined with precision in measuring global cognitive ability in patients with cerebrovascular disease (CVD) or vascular dementia (VaD). Longer tests (e.g. the CAMCOG) are precise but inefficient, whereas brief tests (e.g. the MMSE) are efficient but imprecise.; Methods: A simulated computerized adaptive testing (CAT) algorithm using existing CAMCOG […]