This database contains 542 studies, archived under the term: "middle aged"
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Acupressure in insomnia and other sleep disorders in elderly institutionalized patients suffering from Alzheimer’s disease
Simoncini, M.,
Gatti, A.,
Quirico, P. E.,
Balla, S.,
Capellero, B.,
Obialero, R.,
D'Agostino, S.,
Sandri, N.,
Pernigotti, L. M.
BACKGROUND: Sleep disorders are very common in elderly institutionalized people with dementia and acupressure recently has been associated with conventional medicine in their treatment. AIMS: Exploring the effectiveness of acupressure for the treatment of insomnia and other sleep disturbances and we want to show that the acupressure treatment is feasible also in elderly resident patients. […]
Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial
Zhang, Y.,
Lin, C.,
Zhang, L.,
Cui, Y.,
Gu, Y.,
Guo, J.,
Wu, D.,
Li, Q.,
Song, W.
OBJECTIVES: To explore the efficacy of Chinese herbal formula compared with donepezil 5 mg/day in patients with mild Alzheimer’s disease (AD). METHODS: Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group during the 24-week trial. The outcomes were measured by ADAS-cog, […]
Efficacy of Souvenaid in mild Alzheimer’s disease: results from a randomized, controlled trial
Scheltens, Philip,
Twisk, Jos W.R.,
Blesa, Rafael,
Scarpini, Elio,
von Arnim, Christine A. F.,
Bongers, Anke,
Harrison, John,
Swinkels, Sophie H. N.,
Stam, Cornelis J.,
de Waal, Hanneke,
Wurtman, Richard J.,
Wieggers, Rico L.,
Vellas, Bruno,
Kamphuis, Patrick J. G. H.
Souvenaid aims to improve synapse formation and function. An earlier study in patients with Alzheimer’s disease (AD) showed that Souvenaid increased memory performance after 12 weeks in drug-naïve patients with mild AD. The Souvenir II study was a 24-week, randomized, controlled, double-blind, parallel-group, multi-country trial to confirm and extend previous findings in drug-naïve patients with […]
Two-year effects of an interdisciplinary intervention on recovery following hip fracture in older Taiwanese with cognitive impairment
Shyu, Yea-Ing L.,
Tsai, Wen-Che,
Chen, Min-Chi,
Liang, Jersey,
Cheng, Huey-Shinn,
Wu, Chi-Chuan,
Su, Juin-Yih,
Chou, Shih-Wei
Objective: This article aims to evaluate the long-term effects of an interdisciplinary intervention program on cognitively impaired older persons after hip fracture in Taiwan.; Methods: Of 160 subjects randomly assigned to control (n = 81) and intervention (n = 79) groups, 24 (29.6%) and 27 (34.2%) were cognitively impaired in the control and intervention groups, […]
REMCARE: reminiscence groups for people with dementia and their family caregivers – effectiveness and cost-effectiveness pragmatic multicentre randomised trial
Woods, R. T.,
Bruce, E.,
Edwards, R. T.,
Elvish, R.,
Hoare, Z.,
Hounsome, B.,
Keady, J.,
Moniz-Cook, E. D.,
Orgeta, V.,
Orrell, M.,
Rees, J.,
Russell, I. T.
Objectives: The aim of the REMiniscence groups for people with dementia and their family CAREgivers (REMCARE) study was to assess the effectiveness and cost-effectiveness of joint reminiscence groups for people with dementia and their family caregivers as compared with usual care.; Design: A multicentre, pragmatic randomised controlled trial with two parallel arms – an intervention […]
Preventing loss of independence through exercise (PLIE): a pilot clinical trial in older adults with dementia
Barnes, D. E.,
Mehling, W.,
Wu, E.,
Beristianos, M.,
Yaffe, K.,
Skultety, K.,
Chesney, M. A.
BACKGROUND: Current dementia medications have small effect sizes, many adverse effects and do not change the disease course. Therefore, it is critically important to study alternative treatment strategies. The goal of this study was to pilot-test a novel, integrative group exercise program for individuals with mild-to-moderate dementia called Preventing Loss of Independence through Exercise (PLIE), […]