This database contains 366 studies, archived under the term: "methods"
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Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial
Pitkälä, Kaisu H.,
Pöysti, Minna M.,
Laakkonen, Marja-Liisa,
Tilvis, Reijo S.,
Savikko, Niina,
Kautiainen, Hannu,
Strandberg, Timo E.
Importance: Few rigorous clinical trials have investigated the effectiveness of exercise on the physical functioning of patients with Alzheimer disease (AD).; Objectives: To investigate the effects of intense and long-term exercise on the physical functioning and mobility of home-dwelling patients with AD and to explore its effects on the use and costs of health and […]
Video prompting versus other instruction strategies for persons with Alzheimer’s disease
Perilli, V.,
Lancioni, G. E.,
Hoogeveen, F.,
Caffo, A.,
Singh, N.,
O'Reilly, M.,
Sigafoos, J.,
Cassano, G.,
Oliva, D.
Background/aim: Two studies assessed the effectiveness of video prompting as a strategy to support persons with mild and moderate Alzheimer’s disease in performing daily activities.; Methods: In study I, video prompting was compared to an existing strategy relying on verbal instructions. In study II, video prompting was compared to another existing strategy relying on static […]
Peaceful Mind: an open trial of cognitive-behavioral therapy for anxiety in persons with dementia
Paukert, Amber L.,
Calleo, Jessica,
Kraus-Schuman, Cynthia,
Snow, Lynn,
Wilson, Nancy,
Petersen, Nancy J.,
Kunik, Mark E.,
Stanley, Melinda A.
Background: Anxiety has a high prevalence among individuals with dementia, and it has a significant negative impact on their functioning; yet intervention studies are lacking. We developed Peaceful Mind, a cognitive-behavioral intervention for persons with dementia. In this paper, we describe the intervention and results of an open trial evaluating the feasibility and utility of […]
Effect of treatment gaps in elderly patients with dementia treated with cholinesterase inhibitors
Pariente, A.,
Fourrier-Reglat, A.,
Bazin, F.,
Ducruet, T.,
Dartigues, J. F.,
Dragomir, A.,
Perreault, S.,
Moore, N.,
Moride, Y.
Objective: To determine the effect of treatment gaps on the risk of institutionalization or death among community-dwelling elderly patients treated with cholinesterase inhibitors (ChIs).; Methods: A survival analysis was conducted among a cohort of community-dwelling elderly patients (age 66+) newly treated with ChIs identified in the Quebec drug claims databases (Régie de l’Assurance Maladie du […]
Motor effects of REAC in advanced Alzheimer’s disease: results from a pilot trial
Olazarán, Javier,
González, Belén,
López-Álvarez, Jorge,
Castagna, Alessandro,
Osa-Ruiz, Emma,
Herrero-Cano, Vanesa,
Agüera-Ortiz, Luis,
Rinaldi, Salvatore,
Martínez-Martín, Pablo
We conducted a pilot, randomized, controlled trial to mainly investigate the feasibility, safety, and short-term motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technology in patients with advanced Alzheimer’s disease (AD) who also experience some gait dysfunction. Neuropostural optimization (NPO) or sham protocol was administered to 31 nursing home patients (mean [SD] […]
Pilot controlled trial of mindfulness meditation and education for dementia caregivers
Oken, Barry S.,
Fonareva, Irina,
Haas, Mitchell,
Wahbeh, Helane,
Lane, James B.,
Zajdel, Daniel,
Amen, Alexandra
Objectives: The objectives of this study were to evaluate whether a mindfulness meditation intervention may be effective in caregivers of close relatives with dementia and to help refine the protocol for future larger trials.; Design: The design was a pilot randomized trial to evaluate the effectiveness of a mindfulness meditation intervention adapted from the Mindfulness-Based […]
Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia
Okada, Kaoru,
Kurita, Akira,
Takase, Bonpei,
Otsuka, Toshiaki,
Kodani, Eitaro,
Kusama, Yoshiki,
Atarashi, Hirotsugu,
Mizuno, Kyoichi
Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catecholamine levels in elderly patients with CVD […]
18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias
O'Brien, J. T.,
Firbank, M. J.,
Davison, C.,
Barnett, N.,
Bamford, C.,
Donaldson, C.,
Olsen, K.,
Herholz, K.,
Williams, D.,
Lloyd, J.
Unlabelled: Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken.; Methods: Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and […]