This database contains 366 studies, archived under the term: "methods"
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Therapeutic conversation to improve mood in nursing home residents with Alzheimer’s disease
Few studies have tested strategies to address the mental health needs of individuals with Alzheimer’s disease (AD). To test a newly developed, empirically based modified counseling approach, 30 nursing home residents with AD were randomly assigned to a modified counseling (Therapeutic Conversation) treatment group or usual care control group. Mini-Mental State Examination mean scores were […]
New insights into clinical trial for Colostrinin in Alzheimer’s disease
Szaniszlo, P.,
German, P.,
Hajas, G.,
Saenz, D. N.,
Kruzel, M.,
Boldogh, I.
Background: The pathomechanism of Alzheimer’s disease (AD) is multifactorial although the most popular hypotheses are centered on the effects of the misfolded, aggregated protein, amyloid beta (Abeta) and on Tau hyperphosphorylation.; Objectives: Double blinded clinical trials were planned to demonstrate the effect of Colostrinin (CLN) on instrumental daily activities of AD patients. The potential molecular […]
Use of multisensory environments in the home for people with dementia
The purpose of this pilot study was to explore the feasibility and effectiveness of using multisensory environments (MSE) in the home of people with dementia. A qualitative research design was used, which included semi-structured interviews and self-rated caregiver observation checklists. Field notes and audio recorded interviews were transcribed for data analysis. Data were reduced and […]
Addenbrooke’s Cognitive Examination validation in Parkinson’s disease
Reyes, M. A.,
Perez-Lloret, S.,
Roldan Gerschcovich, E.,
Martin, M. E.,
Leiguarda, R.,
Merello, M.
Background: There is a clear need for brief, sensitive and specific cognitive screening instruments in Parkinson’s disease (PD).; Objectives: To study Addenbrooke’s Cognitive Examination (ACE) validity for cognitive assessment of PD patient’s using the Mattis Dementia Rating Scale (MDRS) as reference method. A specific scale for cognitive evaluation in PD, in this instance the Scales […]
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
Relkin, Norman R.,
Szabo, Paul,
Adamiak, Basia,
Burgut, Tuna,
Monthe, Carmen,
Lent, Richard W.,
Younkin, Steven,
Younkin, Linda,
Schiff, Richard,
Weksler, Marc E.
Intravenous immunoglobulin (IVIg) has been proposed as a potential agent for Alzheimer’s disease (AD) immunotherapy because it contains antibodies against beta-amyloid (Abeta). We carried out an open label dose-ranging study in 8 mild AD patients in which IVIg was added to approved AD therapies for 6 months, discontinued, and then resumed for another 9 months. […]
Voxel-based morphometry in individual patients: a pilot study in early Huntington disease
Mühlau, M.,
Wohlschläger, A. M.,
Gaser, C.,
Valet, M.,
Weindl, A.,
Nunnemann, S.,
Peinemann, A.,
Etgen, T.,
Ilg, R.
Background and Purpose: Voxel-based morphometry (VBM) has proved a powerful method to detect subtle changes of gray matter (GM) at the group level but the role of VBM for the detection of GM changes in single subjects, especially in those with suspected neurodegenerative disorder, remains uncertain. Here, we performed single subject analyses in 22 patients […]
Mobility training after hip fracture: a randomised controlled trial
Moseley, Anne M.,
Sherrington, Catherine,
Lord, Stephen R.,
Barraclough, Elizabeth,
St George, Rebecca J.,
Cameron, Ian D.
Objective: to compare the effects of two different exercise programmes after hip fracture.; Design: assessor-blinded randomised controlled trial.; Setting: hospital rehabilitation units, with continued intervention at home.; Subjects: 160 people with surgical fixation for hip fracture transferred to inpatient rehabilitation.; Method: in addition to other rehabilitation strategies, the intervention group received a higher dose (60 […]
Effectiveness of a psychoeducational intervention program in the reduction of caregiver burden in Alzheimer’s disease patients’ caregivers
Martín-Carrasco, Manuel,
Martín, Manuel Franco,
Valero, Carmelo Pelegrín,
Millán, Pedro Roy,
García, Celso Iglesias,
Montalbán, Salvador Ros,
Vázquez, Ana Luisa Gobartt,
Piris, Sonia Pons,
Vilanova, Montserrat Balañá
Objectives: Caregivers of patients with Alzheimer’s disease (AD) experience physical and psychological stress due to the caring experience. This study evaluated the benefits of a Psychoeducational Intervention Program (PIP) on caregiver burden in southern Europe.; Methods: A multicentre, prospective, randomised study was conducted. One hundred and fifteen caregivers of patients with clinical diagnosis of AD […]