This database contains 73 studies, archived under the term: "longitudinal studies"
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The effects of a long-term care walking program on balance, falls and well-being
Background: The effects of a regular and graduated walking program as a stand-alone intervention for individuals in long-term care are unclear. Exercise and fall prevention programs typically studied in long-term care settings tend to involve more than one exercise mode, such as a combination of balance, aerobic, strengthening, and flexibility exercises; and, measures do not […]
Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial
Ballard, Clive,
Jones, Emma,
Gauge, Nathan,
Aarsland, Dag,
Nilsen, Odd Bjarte,
Saxby, Brian K.,
Lowery, David,
Corbett, Anne,
Wesnes, Keith,
Katsaiti, Eirini,
Arden, James,
Amoako, Derek,
Prophet, Nicholas,
Purushothaman, Balaji,
Green, David
Background: The study determined the one year incidence of post operative cognitive decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic intervention in reducing post-operative cognitive impairment in older adults (over 60 years of age) undergoing elective orthopaedic or abdominal surgery.; Methods and Trial Design: The design was a prospective cohort study with a […]
Acupressure in insomnia and other sleep disorders in elderly institutionalized patients suffering from Alzheimer’s disease
Simoncini, M.,
Gatti, A.,
Quirico, P. E.,
Balla, S.,
Capellero, B.,
Obialero, R.,
D'Agostino, S.,
Sandri, N.,
Pernigotti, L. M.
BACKGROUND: Sleep disorders are very common in elderly institutionalized people with dementia and acupressure recently has been associated with conventional medicine in their treatment. AIMS: Exploring the effectiveness of acupressure for the treatment of insomnia and other sleep disturbances and we want to show that the acupressure treatment is feasible also in elderly resident patients. […]
The effect of regular walks on various health aspects in older people with dementia: protocol of a randomized-controlled trial
Background: Physical activity has proven to be beneficial for physical functioning, cognition, depression, anxiety, rest-activity rhythm, quality of life (QoL), activities of daily living (ADL) and pain in older people. The aim of this study is to investigate the effect of walking regularly on physical functioning, the progressive cognitive decline, level of depression, anxiety, rest-activity […]
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
Heaton, Robert K.,
Franklin, Donald R.,
Ellis, Ronald J.,
McCutchan, J. Allen,
Letendre, Scott L.,
Leblanc, Shannon,
Corkran, Stephanie H.,
Duarte, Nichole A.,
Clifford, David B.,
Woods, Steven P.,
Collier, Ann C.,
Marra, Christina M.,
Morgello, Susan,
Mindt, Monica Rivera,
Taylor, Michael J.,
Marcotte, Thomas D.,
Atkinson, J. Hampton,
Wolfson, Tanya,
Gelman, Benjamin B.,
McArthur, Justin C.,
Simpson, David M.,
Abramson, Ian,
Gamst, Anthony,
Fennema-Notestine, Christine,
Jernigan, Terry L.,
Wong, Joseph,
Grant, Igor
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the […]
A comparison of performance-based measures of function in HIV-associated neurocognitive disorders
Gandhi, Nishiena S.,
Skolasky, Richard L.,
Peters, Katherine B.,
Moxley, Richard T. th,
Creighton, Jason,
Roosa, Heidi Vornbrock,
Selnes, Ola A.,
McArthur, Justin,
Sacktor, Ned
The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test […]
Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe
Eisele, Marion,
Zimmermann, Thomas,
Köhler, Mirjam,
Wiese, Birgitt,
Heser, Kathrin,
Tebarth, Franziska,
Weeg, Dagmar,
Olbrich, Julia,
Pentzek, Michael,
Fuchs, Angela,
Weyerer, Siegfried,
Werle, Jochen,
Leicht, Hanna,
König, Hans-Helmut,
Luppa, Melanie,
Riedel-Heller, Steffi,
Maier, Wolfgang,
Scherer, Martin
Background: Social support has been suggested to positively influence cognition and mortality in old age. However, this suggestion has been questioned due to inconsistent operationalisations of social support among studies and the small number of longitudinal studies available. This study aims to investigate the influence of perceived social support, understood as the emotional component of […]
Extended results of the Alzheimer’s disease anti-inflammatory prevention trial
Breitner, John C.,
Baker, Laura D.,
Montine, Thomas J.,
Meinert, Curtis L.,
Lyketsos, Constantine G.,
Ashe, Karen H.,
Brandt, Jason,
Craft, Suzanne,
Evans, Denis E.,
Green, Robert C.,
Ismail, M. Saleem,
Martin, Barbara K.,
Mullan, Michael J.,
Sabbagh, Marwan,
Tariot, Pierre N.
Background: Epidemiologic evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) delay onset of Alzheimer’s dementia (AD), but randomized trials show no benefit from NSAIDs in patients with symptomatic AD. The Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT) randomized 2,528 elderly persons to naproxen or celecoxib versus placebo for 2 years (standard deviation = 11 months) before treatments […]