Mizukami, Katsuyoshi, Asada, Takashi, Kinoshita, Toru, Tanaka, Katsuaki, Sonohara, Kazuki, Nakai, Ryuhei, Yamaguchi, Kiyoshi, Hanyu, Haruo, Kanaya, Kiyoshi, Takao, Tetsuya, Okada, Masakatsu, Kudo, Sumio, Kotoku, Hayato, Iwakiri, Masahiko, Kurita, Hirofumi, Miyamura, Toshihiro, Kawasaki, Yosuke, Omori, Koji, Shiozaki, Kazumasa, Odawara, Toshinari, Suzuki, Tatsuya, Yamada, Shizuru, Nakamura, Youichi, Toba, Kenji

The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine (kampo) for the treatment of the behavioural and psychological symptoms of dementia (BPSD), were evaluated in 106 patients diagnosed as having Alzheimer’s disease (AD) (including mixed-type dementia) or dementia with Lewy bodies. Patients were randomly assigned to group A (TJ-54 treatment in period I […]

Teranishi, Mika, Kurita, Masatake, Nishino, Satoshi, Takeyoshi, Kenji, Numata, Yukio, Sato, Tadahiro, Tateno, Amane, Okubo, Yoshiro

The descriptive term behavioral and psychological symptoms of dementia (BPSD) is used to cover a range of noncognitive disturbances including anxiety, depression, irritability, aggression, agitation, eating disorders, and inappropriate social or sexual behaviors. Behavioral and psychological symptoms of dementia are seen in about 90% of patients with dementia. We aimed to compare the efficacy and […]

SHINAGAWA, Shunichiro, YATABE, Yusuke, Hashimoto, Mamoru, NAKAYAMA, Kazuhiko, Ikeda, Manabu

Background: Family members’ observations of daily life are important for the diagnosis and treatment of dementia. However, elderly people are increasingly living alone, and family structures tend to differ between inner-city areas and regional areas. We aimed to compare the family caregiving infrastructure of demented elderly visiting a memory clinic.; Methods: Subjects were consecutive outpatients […]

Nakamura, Yu, Kitamura, Shin, Homma, Akira, Shiosakai, Kazuhito, Matsui, Daiju

Background: With the increase in the aging population, there is a pressing need to provide effective treatment options for individuals with Alzheimer’s disease (AD). Memantine is an N-methyl-D-aspartate receptor antagonist used to treat AD in > 80 countries worldwide, and studies in the USA and Europe have shown it to be effective in improving language […]

Kazui, Hiroaki, Mori, Etsuro, Hashimoto, Masaaki, Ishikawa, Masatsune, Hirono, Nobutsugu, Takeda, Masatoshi

Background/aims: Patients with idiopathic normal pressure hydrocephalus (iNPH) are often given shunt operations to reduce the triad symptoms (cognitive impairment, gait disturbance and urinary disturbance). We examined whether they also reduce caregiver burden.; Methods: The personal strain (PS) and role strain (RS) factors, which are related to the stress and constraints, respectively, on the caregivers […]

Ikegami, Naoki, Ikezaki, Sumie

Objectives: To describe end-of-life care in Japanese nursing homes by comparing facility and characteristics of residents dying in nursing homes with those who had been transferred and had died in hospitals, and by comparing the quality of end-of-life care with hospitals and with their respective counterparts in the United States.; Setting: National sample of 653 […]

Gibbons, Laura E., McCurry, Susan, Rhoads, Kristoffer, Masaki, Kamal, White, Lon, Borenstein, Amy R., Larson, Eric B., Crane, Paul K.

Background: The Cognitive Abilities Screening Instrument (CASI) was designed for use in cross-cultural studies of Japanese and Japanese-American elderly in Japan and the U.S.A. The measurement equivalence in Japanese and English had not been confirmed in prior studies.; Methods: We analyzed the 40 CASI items for differential item functioning (DIF) related to test language, as […]

Fujiwara, Yoshinori, Suzuki, Hiroyuki, Yasunaga, Masashi, Sugiyama, Mika, Ijuin, Mutsuo, Sakuma, Naoko, Inagaki, Hiroki, Iwasa, Hajime, Ura, Chiaki, Yatomi, Naomi, Ishii, Kenji, Tokumaru, Aya M, Homma, Akira, Nasreddine, Ziad, Shinkai, Shoji

Aim: The Montreal Cognitive Assessment (MoCA), developed by Dr Nasreddine (Nasreddine et al. 2005), is a brief cognitive screening tool for detecting older people with mild cognitive impairment (MCI). We examined the reliability and validity of the Japanese version of the MoCA (MoCA-J) in older Japanese subjects.; Methods: Subjects were recruited from the outpatient memory […]