Peters, Ruth, Beckett, Nigel, Fagard, Robert, Thijs, Lutgarde, Wang, Ji-Guang, Forette, Francoise, Pereira, Lisa, Fletcher, Astrid, Bulpitt, Christopher

Objectives: High blood pressure (BP) has been associated with increased risk of dementia. Concerns have been raised about lowering BP too far in the very elderly and thereby increasing risk. There is some evidence to suggest a potential ‘J’-shaped relationship between DBP and risk of cognitive impairment. This was investigated using data from the HYpertension […]

Hajjar, Ihab, Hart, Meaghan, Chen, Yu-Ling, Mack, Wendy, Novak, Vera, C. Chui, Helena, Lipsitz, Lewis

Objectives: To compare the effects of three antihypertensive medications on cerebral hemodynamic and cognitive function in hypertensive individuals with executive dysfunction.; Design: Double-blind randomized clinical trial.; Setting: Community.; Participants: Fifty-three individuals aged 60 and older with hypertension and executive dysfunction.; Intervention: Lisinopril, candesartan, or hydrochlorothiazide for 1 year.; Measurements: Cerebral blood flow velocity (BFV; transcranial […]

Bermejo-Pareja, Félix, Benito-León, Julián, Louis, Elan D., Trincado, Rocío, Carro, Eva, Villarejo, Alberto, de la Cámara, Agustín Gómez

Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]