This database contains 1231 studies, archived under the term: "humans"
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Development and validation of the mortality risk for trauma comorbidity index
Thompson, Hilaire J.,
Rivara, Frederick P.,
Nathens, Avery,
Wang, Jin,
Jurkovich, Gregory J.,
Mackenzie, Ellen J.
Objective: The aim of this study was to develop and validate a comorbidity index to predict the risk of mortality associated with chronic health conditions following a traumatic injury.; Summary Background Data: Currently available comorbidity adjustment tools do not account for certain chronic conditions, which may influence outcome following traumatic injury or they have not […]
A comparison of neurocognitive impairment in younger and older adults with major depression
Thomas, A. J.,
Gallagher, P.,
Robinson, L. J.,
Porter, R. J.,
Young, A. H.,
Ferrier, I. N.,
O'Brien, J. T.
Background: Neurocognitive impairment is a well-recognized feature of depression that has been reported in younger and older adults. Similar deficits occur with ageing and it is unclear whether the greater deficits in late-life depression are an ageing-related phenomenon or due to a difference in the nature of late-life depression itself. We hypothesized that ageing alone […]
Staff training in assisted living: evaluating treatment fidelity
Teri, Linda,
McKenzie, Glenise L.,
Pike, Kenneth C.,
Farran, Carol J.,
Beck, Cornelia,
Paun, Olimpia,
LaFazia, David
Objectives: To investigate a protocol for identifying and evaluating treatment fidelity in Staff Training in Assisted-living Residences (STAR), a structured but flexible program to train direct care staff to improve care of residents with dementia.; Design: Multisite feasibility trial.; Setting: Assisted living facilities (ALFs).; Participants: Forty-four direct care staff and 36 leadership staff.; Intervention: STAR […]
Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial
Teranishi, Mika,
Kurita, Masatake,
Nishino, Satoshi,
Takeyoshi, Kenji,
Numata, Yukio,
Sato, Tadahiro,
Tateno, Amane,
Okubo, Yoshiro
The descriptive term behavioral and psychological symptoms of dementia (BPSD) is used to cover a range of noncognitive disturbances including anxiety, depression, irritability, aggression, agitation, eating disorders, and inappropriate social or sexual behaviors. Behavioral and psychological symptoms of dementia are seen in about 90% of patients with dementia. We aimed to compare the efficacy and […]
Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion imaging in mild Alzheimer’s disease
Terada, Seishi,
Sato, Shuhei,
Honda, Hajime,
Kishimoto, Yuki,
Takeda, Naoya,
Oshima, Etsuko,
Yokota, Osamu,
Uchitomi, Yosuke
Background: The Wisconsin Card Sorting Test (WCST) has long been used to investigate deficits in executive function in humans. The majority of studies investigating deficient WCST performance focused on the number of categories achieved (CA) and the number of perseverative errors of the Nelson type (PEN). However, there is insufficient evidence that these two measures […]
Decision-making and outcomes of feeding tube insertion: a five-state study
Teno, Joan M.,
Mitchell, Susan L.,
Kuo, Sylvia K.,
Gozalo, Pedro L.,
Rhodes, Ramona L.,
Lima, Julie C.,
Mor, Vincent
Objectives: To examine family member’s perceptions of decision-making and outcomes of feeding tubes.; Design: Mortality follow-back survey. Sample weights were used to account for oversampling and survey design. A multivariate model examined the association between feeding tube use and overall quality of care rating regarding the last week of life.; Setting: Nursing homes, hospitals, and […]
Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
Teipel, Stefan J.,
Reuter, Sigrid,
Stieltjes, Bram,
Acosta-Cabronero, Julio,
Ernemann, Ulrike,
Fellgiebel, Andreas,
Filippi, Massimo,
Frisoni, Giovanni,
Hentschel, Frank,
Jessen, Frank,
Klöppel, Stefan,
Meindl, Thomas,
Pouwels, Petra J.W.,
Hauenstein, Karl-Heinz,
Hampel, Harald
Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]
Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia
Tay, Laura,
Chua, Kia Chong,
Chan, Mark,
Lim, Wee Shiong,
Ang, Yue Ying,
Koh, Evonne,
Chong, Mei Sian
Background: Discordance between patient- and caregiver-reported quality of life (QoL) is well recognized. This study sought to (i) identify predictors of discrepancy between patient- and caregiver-rated QoL amongst community-dwelling persons with mild-to-moderate dementia, and (ii) differentiate between patients who systematically rate their QoL lower versus those who rate their QoL higher relative to their caregiver […]
Infection hospitalization increases risk of dementia in the elderly
Tate, Judith A.,
Snitz, Beth E.,
Alvarez, Karina A.,
Nahin, Richard L.,
Weissfeld, Lisa A.,
Lopez, Oscar,
Angus, Derek C.,
Shah, Faraaz,
Ives, Diane G.,
Fitzpatrick, Annette L.,
Williamson, Jeffrey D.,
Arnold, Alice M.,
DeKosky, Steven T.,
Yende, Sachin
Objectives: Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults.; Design: Secondary analysis of a randomized multicenter […]