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This database contains 1231 studies, archived under the term: "humans"

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Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice
The efficacy and safety of the kampo medicine Yokukansan (YKS, TJ-54) in the treatment of behavioral and psychological symptoms of dementia (BPSD) were investigated in patients with Alzheimer’s disease (AD) in an open-label study. This study included 26 patients who had been diagnosed as having AD and were not treated with donepezil hydrochloride. These patients […]

The social treatment: the benefits of group interventions in residential care settings
We report findings from an intervention study that investigates the impact of group reminiscence (GR) and individual reminiscence (IR) activities on older adults living in care settings. This research aimed to provide a theory-driven evaluation of reminiscence based on a social identity framework. This framework predicts better health outcomes for group-based interventions as a result […]

Counsellors contact dementia caregivers–predictors of utilisation in a longitudinal study
Background: Counselling of family members is an established procedure in the support of dementia patients’ relatives. In absence of widespread specialised dementia care services in most countries, however, counselling services are often not taken up or only very late in the course of the disease.; Object: In order to promote acceptance of this service, a […]

Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention
Objectives: To test the effects of an intervention that helps families manage distressing behaviors in family members with dementia.; Design: Two-group randomized trial.; Setting: In home.; Participants: Two hundred seventy-two caregivers and people with dementia.; Intervention: Up to 11 home and telephone contacts over 16 weeks by health professionals who identified potential triggers of patient […]

The cost-effectiveness of a nonpharmacologic intervention for individuals with dementia and family caregivers: the tailored activity program
Objectives: To evaluate cost-effectiveness of the Tailored Activity Program (TAP) for individuals with dementia and family caregivers.; Design: Cost-effectiveness study of a two-group randomized controlled trial involving 60 patients-caregiver dyads randomized to intervention or wait-list control.; Setting: Participants’ homes in Philadelphia region.; Participants: Caregivers were aged ≥ 21 years, lived with patients, and provided ≥ […]

Using Talking Mats to support communication in persons with Huntington’s disease
Background: Many individuals with Huntington’s disease experience reduced functioning in cognition, language and communication. Talking Mats is a visually based low technological augmentative communication framework that supports communication in people with different cognitive and communicative disabilities.; Aims: To evaluate Talking Mats as a communication tool for people in the later stages of Huntington’s disease.; Methods& […]

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
Background: There is some evidence that statins may have a protective and symptomatic benefit in Alzheimer disease (AD). The LEADe study is a randomized controlled trial (RCT) evaluating the efficacy and safety of atorvastatin in patients with mild to moderate AD.; Methods: This was an international, multicenter, double-blind, randomized, parallel-group study. Subjects had mild to […]

Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer’s disease: A 24-week, randomized, double-blind study
Background: Currently approved Alzheimer’s disease (AD) treatments have been reported to provide symptomatic benefit, without proven impact on clinical progression. We hypothesized that the loss of initial therapeutic benefit over time may be mitigated by higher doses of a cholinesterase inhibitor.; Objective: The aim of this study was to determine the effectiveness and tolerability of […]

A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer’s disease: a post hoc analysis
Objective: To investigate the tolerability and efficacy of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer’s disease receiving concomitant memantine.; Research Design and Methods: Post hoc analysis of a 25-week, randomized, prospective, open-label, parallel-group study. Patients receiving donepezil were switched to rivastigmine patches (4.6 mg/24 h) immediately or following a 7-day withdrawal for 4 […]

Effects of general practitioner training and family support services on the care of home-dwelling dementia patients–results of a controlled cluster-randomized study
Background: More than 90% of dementia patients are cared for by their general practitioners, who are decisively involved in the diagnosis, therapy and recommendation of support services.; Objective: To test whether special training of general practitioners alters the care of dementia patients through their systematic recommendation of caregiver counseling and support groups.; Method: 129 general […]

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