This database contains 1231 studies, archived under the term: "humans"
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Effect of a high-intensity functional exercise program on functional balance: preplanned subgroup analyses of a randomized controlled trial in residential care facilities
Littbrand, Håkan,
Carlsson, Maine,
Lundin-Olsson, Lillemor,
Lindelöf, Nina,
Håglin, Lena,
Gustafson, Yngve,
Rosendahl, Erik
Objectives: To evaluate whether age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity influences the effect of a high-intensity functional weight-bearing exercise program on functional balance.; Design: Preplanned subgroup analyses of a randomized controlled trial.; Setting: Nine residential care facilities.; Participants: One hundred ninety-one people aged 65 to 100 dependent in […]
Deep learning based imaging data completion for improved brain disease diagnosis
Li, Rongjian,
Zhang, Wenlu,
Suk, Heung-Il,
Wang, Li,
Li, Jiang,
Shen, Dinggang,
Ji, Shuiwang
Combining multi-modality brain data for disease diagnosis commonly leads to improved performance. A challenge in using multimodality data is that the data are commonly incomplete; namely, some modality might be missing for some subjects. In this work, we proposed a deep learning based framework for estimating multi-modality imaging data. Our method takes the form of […]
The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease
Lewis, John E.,
McDaniel, H. Reginald,
Agronin, Marc E.,
Loewenstein, David A.,
Riveros, Jorge,
Mestre, Rafael,
Martinez, Mairelys,
Colina, Niurka,
Abreu, Dahlia,
Konefal, Janet,
Woolger, Judi M.,
Ali, Karriem H.
Alzheimer’s disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive […]
More insight into the concept of apathy: a multidisciplinary depression management program has different effects on depressive symptoms and apathy in nursing homes
Leontjevas, Ruslan,
Teerenstra, Steven,
Smalbrugge, Martin,
Vernooij-Dassen, Myrra J. F. J.,
Bohlmeijer, Ernst T.,
Gerritsen, Debby L,
Koopmans, Raymond T. C. M.
Background: Apathy is common in nursing home (NH) residents and it overlaps with depression. This study examines the effects of a multidisciplinary depression program on apathy and depressive motivational and mood symptoms.; Methods: Secondary analyses of a stepped-wedge cluster-randomized controlled trial were conducted with six measurements. Sixteen dementia NH units and 17 somatic units were […]
A structural multidisciplinary approach to depression management in nursing-home residents: a multicentre, stepped-wedge cluster-randomised trial
Leontjevas, Ruslan,
Gerritsen, Debby L,
Smalbrugge, Martin,
Teerenstra, Steven,
Vernooij-Dassen, Myrra JFJ,
Koopmans, Raymond TCM
Background: Depression in nursing-home residents is often under-recognised. We aimed to establish the effectiveness of a structural approach to its management.; Methods: Between May 15, 2009, and April 30, 2011, we undertook a multicentre, stepped-wedge cluster-randomised trial in four provinces of the Netherlands. A network of nursing homes was invited to enrol one dementia and […]
Management of apathy in nursing homes using a teaching program for care staff: the STIM-EHPAD study
Leone, Elsa,
Deudon, Audrey,
Bauchet, Murielle,
Laye, Mathilde,
Bordone, Nathalie,
Lee, Ji-Hyun,
Piano, Julie,
Friedman, Leah,
David, Renaud,
Delva, Fleur,
Brocker, Patrice,
Yesavage, Jerome,
Robert, Philippe Henri
Objective: This study aimed to evaluate the effectiveness of a nursing home (NH) staff education to manage apathy in older individuals with a diagnosis of dementia.; Methods: Sixteen NHs agreed to participate, and 230 demented apathetic residents were randomly assigned to the reference group (RG) or the intervention group (IG). IG received a month of […]
Learning opportunities in a residential aged care facility: the role of supported placements for first-year nursing students
Lea, Emma,
Marlow, Annette,
Bramble, Marguerite,
Andrews, Sharon,
Crisp, Elaine,
Eccleston, Claire,
Mason, Ron,
Robinson, Andrew
The residential aged care sector is reportedly a less attractive career choice for nursing students than other sectors. Research shows that students are often fearful of working with residents with dementia when they are inadequately supported on clinical placements by aged care staff. Thirty first-year nursing students attended a 2-week placement in one of two […]
Comparison of two analytical platforms for the clinical qualification of Alzheimer’s disease biomarkers in pathologically-confirmed dementia
Le Bastard, Nathalie,
Coart, Els,
Vanderstichele, Hugo,
Vanmechelen, Eugeen,
Martin, Jean-Jacques,
Engelborghs, Sebastiaan
Combined analysis of the Alzheimer’s disease (AD) biomarkers amyloid-β(1-42) (Aβ(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests […]