This database contains 5 studies, archived under the term: "european continental ancestry group"
Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease
Uenaka, Kazunori,
Nakano, Masako,
Willis, Brian A.,
Friedrich, Stuart,
Ferguson-Sells, Lisa,
Dean, Robert A.,
Ieiri, Ichiro,
Siemers, Eric R.
Objectives: Solanezumab is a humanized anti-amyloid β monoclonal antibody being developed as a passive immunization treatment to slow the progression of Alzheimer disease (AD). Pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after a single dose of solanezumab were compared between Japanese and white patients with AD.; Methods: Japanese and white patients with mild to moderate AD […]
The association of statin use and statin type and cognitive performance: analysis of the reasons for geographic and racial differences in stroke (REGARDS) study
Glasser, Stephen P.,
Wadley, Virginia,
Judd, Suzanne,
Kana, Bhumika,
Prince, Valerie,
Jenny, Nancy,
Kissela, Brett,
Safford, Monika,
Prineas, Ronald,
Howard, George
Background: Statin use and type have been variably associated with impaired or improved cognitive performance.; Hypothesis: To assess the association of statin use and type (lipophilic vs hydrophilic) and cognitive impairment.; Methods: Cross-sectional analysis of 24 595 participants (7191 statin users and 17 404 nonusers) age > or = 45 years, from a population-based national […]
Effects of age, gender, education and race on two tests of language ability in community-based older adults
Snitz, Beth E.,
Unverzagt, Frederick W.,
Chang, Chung-Chou H.,
Bilt, Joni Vander,
Gao, Sujuan,
Saxton, Judith,
Hall, Kathleen S.,
Ganguli, Mary
Background: Neuropsychological tests, including tests of language ability, are frequently used to differentiate normal from pathological cognitive aging. However, language can be particularly difficult to assess in a standardized manner in cross-cultural studies and in patients from different educational and cultural backgrounds. This study examined the effects of age, gender, education and race on performance […]
Hostility and change in cognitive function over time in older blacks and whites
Barnes, Lisa L.,
Mendes de Leon, Carlos F.,
Bienias, Julia L.,
Wilson, Robert S.,
Everson-Rose, Susan A.,
Evans, Denis A.
Objective: To test whether the level of hostility predicted the rate of cognitive decline in a community of older blacks and whites and whether the association varied as a function of race.; Methods: Over 4800 persons from a defined community in Chicago completed up to three structured interviews at approximately 3 year intervals over a […]