This database contains 9 studies, archived under the term: "diabetes"
Memantine prevents hypoglycemia-induced decrements of the cerebral energy status in healthy subjects
Willenborg, B.,
Schmoller, A.,
Caspary, J.,
Melchert, U. H.,
Scholand-Engler, H. G.,
Jauch-Chara, K.,
Hohagen, F.,
Schweiger, U.,
Oltmanns, K. M.
Context: The risk to develop dementia is significantly increased in diabetes mellitus. Memantine, an N-methyl-D-aspartate receptor antagonist, which is clinically applied in dementia, has been shown to exert neuroprotective effects under hypoglycemic conditions in rats.; Objective: We hypothesized that memantine may prevent hypoglycemia-induced decrements in the cerebral high-energy phosphate, i.e. ATP, metabolism to exert its […]
Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer’s disease
Baker, Laura D.,
Frank, Laura L.,
Foster-Schubert, Karen,
Green, Pattie S.,
Wilkinson, Charles W.,
McTiernan, Anne,
Cholerton, Brenna A.,
Plymate, Stephen R.,
Fishel, Mark A.,
Watson, G. Stennis,
Duncan, Glen E.,
Mehta, Pankaj D.,
Craft, Suzanne
Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes […]
Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment
Abbatecola, Angela M.,
Lattanzio, Fabrizia,
Molinari, Anna M.,
Cioffi, Michele,
Mansi, Luigi,
Rambaldi, Pierfrancesco,
DiCioccio, Luigi,
Cacciapuoti, Federico,
Canonico, Raffaele,
Paolisso, Giuseppe
Objective: Studies have suggested that insulin resistance plays a role in cognitive impairment in individuals with type 2 diabetes. We aimed to determine whether an improvement in insulin resistance could explain cognitive performance variations over 36 weeks in older individuals with mild cognitive impairment (MCI) and type 2 diabetes.; Research Design and Methods: A total […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]
Impaired glucose metabolism slows executive function independent of cerebral ischemic lesions in Japanese elderly: the Takahata study
Takahashi, Yoshimi,
Iseki, Chifumi,
Wada, Manabu,
Momma, Tadasuke,
Ueki, Masao,
Kawanami, Toru,
Daimon, Makoto,
Suzuki, Kyoko,
Tamiya, Gen,
Kato, Takeo
Objective: Age is known to influence the risk of both cerebral ischemic lesions and impaired cognitive function. Diabetes mellitus (DM) can also be associated with cognitive impairment. However, there has been no study of neuropsychological performance in association with glucose metabolism status and cerebral ischemic lesions in same-aged, community-dwelling elderly persons. The present study was […]
Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
Reijmer, Yael D.,
van den Berg, Esther,
de Bresser, Jeroen,
Kessels, Roy P. C.,
Kappelle, L. Jaap,
Algra, Ale,
Biessels, Geert Jan
Background: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes.; Methods: Cognitive functioning and brain volume as well as metabolic and vascular risk factors were assessed twice in […]
Long-term metformin usage and cognitive function among older adults with diabetes
Ng, Tze Pin,
Feng, Liang,
Yap, Keng Bee,
Lee, Tih Shih,
Tan, Chay Hoon,
Winblad, Bengt
Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective […]
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies
Anderson, Craig,
Teo, Koon,
Gao, Peggy,
Arima, Hisatomi,
Dans, Antonio,
Unger, Thomas,
Commerford, Patrick,
Dyal, Leanne,
Schumacher, Helmut,
Pogue, Janice,
Paolasso, Ernesto,
Holwerda, Nicolaas,
Chazova, Irina,
Binbrek, Azan,
Young, James,
Yusuf, Salim
Background: cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials.; Methods: in the main study, ONTARGET, a double-blind, double-dummy, randomised controlled trial, […]