Fehlbaum-Beurdeley, Pascale, Sol, Olivier, Désiré, Laurent, Touchon, Jacques, Dantoine, Thierry, Vercelletto, Martine, Gabelle, Audrey, Jarrige, Anne-Charlotte, Haddad, Raphaël, Lemarié, Jean Christophe, Zhou, Weiyin, Hampel, Harald, Einstein, Richard, Vellas, Bruno

Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer’s disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was then evaluated for robustness in an independent blinded sample population. RNA was extracted […]

Eichler, Tilly, Thyrian, Jochen René, Fredrich, Daniel, Kohler, Leonore, Wucherer, Diana, Michalowsky, Bernhard, Dreier, Adina, Hoffmann, Wolfgang

Background: A computerized Intervention-Management-System (IMS) has been developed and implemented to facilitate dementia care management. IMS is a rule-based expert decision support system that matches individual patient characteristics to a computerized knowledge base. One of the most important functionalities of IMS is to support the compilation of the individual intervention plan by systematically identifying unmet […]

Lee, Chin C., Czaja, Sara J., Schulz, Richard

This article extends the findings from the Resources for Enhancing Alzheimer’s Caregiver Health (REACH II) program, a multisite randomized clinical trial of a multicomponent psychosocial intervention, to improve the well-being of informal caregivers (CGs) of persons with dementia. We used residual change scores and stepwise hierarchical regression analyses to explore separately in 3 racial ethnic […]

Joling, Karlijn J, van Marwijk, Harm W.J., Smit, Filip, van der Horst, Henriëtte E, Scheltens, Philip, van de Ven, Peter M., Mittelman, Mary S., van Hout, Hein P.J.

Background: Family caregivers of dementia patients are at increased risk of developing depression or anxiety. A multi-component program designed to mobilize support of family networks demonstrated effectiveness in decreasing depressive symptoms in caregivers. However, the impact of an intervention consisting solely of family meetings on depression and anxiety has not yet been evaluated. This study […]

Hong, Gwi-Ryung Son

Purpose: The purpose of the study was to examine the effects of multisensory stimulation (MSS) using familiarity on persons with dementia (PWDs) residing in nursing homes in Korea.; Methods: A nonequivalent control group with pre and posttests was used. Fifty one PWDs were included if they: 1) were over 65 yr old, 2) were diagnosed […]

Beer, Christopher, Horner, Barbara, Flicker, Leon, Scherer, Samuel, Lautenschlager, Nicola T., Bretland, Nick, Flett, Penelope, Schaper, Frank, Almeida, Osvaldo P.

Background: The Dementia In Residential care: EduCation intervention Trial (DIRECT) was conducted to determine if delivery of education designed to meet the perceived need of GPs and care staff improves the quality of life of participants with dementia living in residential care.; Methodology/principal Findings: This cluster-randomised controlled trial was conducted in 39 residential aged care […]