This database contains 61 studies, archived under the term: "cohort studies"
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Safety of lumbar puncture procedures in patients with Alzheimer’s disease
Changes in cerebrospinal fluid (CSF) biomarkers are representative of biochemical changes in the brain. Collection of CSF by lumbar puncture (LP) is essential for biomarker analysis, which is important for research in neurodegenerative disorders. However, LP for research purposes has been controversial due to a reported high incidence of severe LP headache when using standard […]
Incidence and prediction of falls in dementia: a prospective study in older people
Background: Falls are a major cause of morbidity and mortality in dementia, but there have been no prospective studies of risk factors for falling specific to this patient population, and no successful falls intervention/prevention trials. This prospective study aimed to identify modifiable risk factors for falling in older people with mild to moderate dementia.; Methods […]
The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer’s disease risk: a prospective cohort study
Keller, Lina,
Xu, Weili,
Wang, Hui-Xin,
Winblad, Bengt,
Fratiglioni, Laura,
Graff, Caroline
The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer’s disease (AD) and dementia. Thus, our aim was to explore the […]
Atypical antipsychotic use and parkinsonism in dementia: effects of drug, dose, and sex
Marras, Connie,
Herrmann, Nathan,
Anderson, Geoffrey M.,
Fischer, Hadas D.,
Wang, Xuesong,
Rochon, Paula A.
Background: Differences between atypical antipsychotics in their potential to cause parkinsonism and risk factors for antipsychotic-induced parkinsonism are not well established. There is a particular paucity of information on this in real-world use of these drugs, outside of clinical trial settings.; Objective: We compared the incidence of parkinsonism after new treatment with risperidone, olanzapine, or […]
Hospice use and outcomes in nursing home residents with advanced dementia
Objectives: To identify characteristics of nursing home (NH) residents with advanced dementia and their healthcare proxies (HCPs) associated with hospice referral and to examine the association between hospice use and the treatment of pain and dyspnea and unmet needs during the last 7 days of life.; Design: Prospective cohort study.; Setting: Twenty-two Boston-area NHs.; Participants: […]
Quality of life in nursing home residents with advanced dementia
Objectives: To examine quality of life (QOL) in nursing home (NH) residents with advanced dementia and identify correlates of QOL near the end of life.; Design: Cross-sectional data derived from NH records, interviews with residents’ surrogate decision-makers, QOL ratings by NH caregivers, and assessment of residents’ cognitive function.; Setting: Three NHs in Maryland.; Participants: A […]
Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease
Daiello, Lori A.,
Ott, Brian R.,
Festa, Elena K.,
Friedman, Michael,
Miller, Lindsay A.,
Heindel, William C.
Objective: We conducted a combined observational cohort and case-control study in patients with Alzheimer disease (AD) to assess the effects of acetylcholinesterase inhibitor (ChEI) treatment on cognitive functions important for driving.; Methods: Performance of 24 outpatients with newly diagnosed (untreated) early-stage AD was compared before beginning ChEI (pre-ChEI) and after 3 months of therapy (post-ChEI) […]
Implementatie, effecten en kosten van casemanagement voor mensen met dementie en hun mantelzorgers: Beschrijving van de COMPAS studie. = Comparing case management care models for people with dementia and their caregivers: The design of the COMPAS study
van Hout, H. P. J.,
Macneil Vroomen, J. L.,
Van Mierlo, L. D.,
Meiland, F. J. M.,
Moll van Charante, E. P.,
Joling, K. J.,
van den Dungen, P.,
Dröes, R. M.,
van der Horst, H. E.,
de Rooij, S. E. J. A.
Background: Dementia care in The Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalized care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in The Netherlands. It is unclear if these […]
Comparing Dutch case management care models for people with dementia and their caregivers: The design of the COMPAS study.
MacNeil Vroomen, Janet,
Van Mierlo, Lisa D.,
van de Ven, Peter M.,
Bosmans, Judith E,
van den Dungen, Pim,
Meiland, Franka J. M.,
Dröes, Rose-Marie,
Moll van Charante, Eric P.,
van der Horst, Henriëtte E,
de Rooij, Sophia E.,
van Hout, Hein P.J.
Background: Dementia care in the Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalised care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in the Netherlands. It is unclear if these […]
Early detection of memory impairment in people over 65 years old consulting at Health Examination Centers for the French health insurance: the EVATEM protocol
Vannier-Nitenberg, Christiane,
Dauphinot, Virginie,
Bongue, Bienvenu,
Sass, Catherine,
Rouch, Isabelle,
Beauchet, Olivier,
Krolak-Salmon, Pierre,
Fantino, Bruno
Background: Only half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive tests for their predictive ability to diagnose mild cognitive impairments and Alzheimer’s disease and related disorders. For people aged 65 […]