This database contains 27 studies, archived under the term: "cognitive"
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Effects of exercise programs to prevent decline in health-related quality of life in highly deconditioned institutionalized elderly persons: a randomized controlled trial
Dechamps, Arnaud,
Diolez, Philippe,
Thiaudière, Eric,
Tulon, Aurore,
Onifade, Chérifa,
Vuong, Tuan,
Helmer, Catherine,
Bourdel-Marchasson, Isabelle
Background: Our objective was to assess the effects of targeted exercise programs on health-related quality of life compared with usual care based on the ability to perform activities of daily living (ADL) and the Neuropsychiatric Inventory scores in geriatric institutionalized persons.; Methods: A randomized controlled trial of 2 exercise programs vs usual care was conducted […]
Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy
Clare, Linda,
Linden, David E. J.,
Woods, Robert T,
Whitaker, Rhiannon,
Evans, Suzannah J.,
Parkinson, Caroline H.,
van Paasschen, Jorien,
Nelis, Sharon M.,
Hoare, Zoe,
Yuen, Kenneth S. L.,
Rugg, Michael D.
Objectives: To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD).; Design: Single-blind randomized controlled trial comparing CR with relaxation therapy and no treatment.; Setting: Outpatient, community-based setting.; Participants: Sixty-nine individuals (41 women, 28 men; mean age 77.78 years, standard deviation 6.32, range = 56-89) with a diagnosis of […]
Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial
Gates, Nicola J.,
Valenzuela, Michael,
Sachdev, Perminder S.,
Singh, Nalin A.,
Baune, Bernhard T.,
Brodaty, Henry,
Suo, Chao,
Jain, Nidhi,
Wilson, Guy C.,
Wang, Yi,
Baker, Michael K.,
Williamson, Dominique,
Foroughi, Nasim,
Fiatarone Singh, Maria A.
Background: The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and […]
The Indiana Alzheimer Disease Center’s Symposium on Mild Cognitive Impairment. Cognitive training in older adults: Lessons from the ACTIVE study
Unverzagt, Frederick,
Smith, David,
Rebok, George,
Marsiske, Michael,
Morris, John,
Jones, Richard,
Willis, Sherry,
Ball, Karlene,
King, Jonathan,
Koepke, Kathy,
Stoddard, Anne,
Tennstedt, Sharon
This paper is based on a presentation made during the Indiana Alzheimer Disease Center’s Symposium on Mild Cognitive Impairment on April 19, 2008. The results of the ACTIVE study (Advanced Cognitive Training for Independent and Vital Elderly) were presented at the symposium including review of previously published study findings. The ACTIVE study is a multicenter, […]
Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
Sierra, Saleta,
Ramos, Maria C.,
Molina, Pilar,
Esteo, Cynthia,
Vázquez, Jose Antonio,
Burgos, Javier S.
There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer’s disease. The mechanisms for neuroprotection are only partially understood, however, and pleiotropic phenomena could be involved. We have made a comparative study of 9 statins (lovastatin, mevastatin, pravastatin, simvastatin, cerivastatin, atorvastatin, fluvastatin, pitavastatin, and rosuvastatin), […]
Anhedonia and cognitive impairment in Parkinson’s disease: Italian validation of the Snaith-Hamilton Pleasure Scale and its application in the clinical routine practice during the PRIAMO study
Santangelo, G.,
Morgante, L.,
Savica, R.,
Marconi, R.,
Grasso, L.,
Antonini, A.,
De Gaspari, D.,
Ottaviani, D.,
Tiple, D.,
Simoni, L.,
Barone, P.
Objective: To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson’s disease (PD).; Methods: The SHAPS (14 items) was translated into Italian and pre-tested in a pilot study. Two items evaluating physical anhedonia related to […]
Impact of smoking on cognitive decline in early old age: the Whitehall II cohort study
Sabia, Séverine,
Elbaz, Alexis,
Dugravot, Aline,
Head, Jenny,
Shipley, Martin,
Hagger-Johnson, Gareth,
Kivimaki, Mika,
Singh-Manoux, Archana
Context: Smoking is a possible risk factor for dementia, although its impact may have been underestimated in elderly populations because of the shorter life span of smokers.; Objective: To examine the association between smoking history and cognitive decline in the transition from midlife to old age.; Design: Cohort study.; Setting: The Whitehall II study. The […]
Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study
Rabey, Jose M.,
Dobronevsky, Evgenia,
Aichenbaum, Sergio,
Gonen, Ofer,
Marton, Revital Gendelman,
Khaigrekht, Michael
Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer’s disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD. Fifteen AD patients received 1-h daily rTMS-COG or […]