Liu, Justina Yat Wa, Lai, Claudia

Background: Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia. Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol, which should include score interpretation and verification with appropriately suggested treatments. The Observational Pain […]

Thyrian, Jochen René, Fiß, Thomas, Dreier, Adina, Böwing, Georgia, Angelow, Aniela, Lueke, Sven, Teipel, Stefan, Fleßa, Steffen, Grabe, Hans Jörgen, Freyberger, Harald Jürgen, Hoffmann, Wolfgang

Background: The provision of appropriate medical and nursing care for people with dementia is a major challenge for the healthcare system in Germany. New models of healthcare provision need to be developed, tested and implemented on the population level. Trials in which collaborative care for dementia in the primary care setting were studied have demonstrated […]

Voigt-Radloff, Sebastian, Graff, Maud, Leonhart, Rainer, Schornstein, Katrin, Vernooij-Dassen, Myrra, Olde Rikkert, Marcel, Huell, Michael

Background: A recent Dutch mono-centre randomised controlled trial has shown that occupational therapy improves daily functioning in dementia. The aim of this present study is to compare the effects of the Dutch community occupational therapy programme with a community occupational therapy consultation on daily functioning in older people with mild or moderate dementia and their […]

Annweiler, Cedric, Fantino, Bruno, Parot-Schinkel, Elsa, Thiery, Samuel, Gautier, Jennifer, Beauchet, Olivier

Background: Current treatments for Alzheimer’s disease and related disorders (ADRD) are symptomatic and can only temporarily slow down ADRD. Future possibilities of care rely on multi-target drugs therapies that address simultaneously several pathophysiological processes leading to neurodegeneration. We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal […]

Pitkälä, Kaisu H., Raivio, Minna M., Laakkonen, Marja-Liisa, Tilvis, Reijo S., Kautiainen, Hannu, Strandberg, Timo E.

Background: Besides cognitive decline, Alzheimer’s disease (AD) leads to physical disability, need for help and permanent institutional care. The trials investigating effects of exercise rehabilitation on physical functioning of home-dwelling older dementia patients are still scarce. The aim of this study is to investigate the effectiveness of intensive exercise rehabilitation lasting for one year on […]

WALDEMAR, G., Waldorff, F. B., Buss, D. V., Eckermann, A., Keiding, N., Rishøj, S., Siersma, V., Sørensen, J., Sørensen, L. V., VOGEL, A.

Background: There is a lack of appropriately designed trials investigating the efficacy of psychosocial interventions for patients with mild dementia and their family caregivers. This paper reports the rationale and design of the Danish Alzheimer Disease Intervention Study and baseline characteristics of the cohort.; Methods: The study was a 1-year multicentre randomized controlled rater-blinded trial […]

Husebo, B. S., Ballard, C., Sandvik, R., Nilsen, O. B., Aarsland, D.

Objective: To determine whether a systematic approach to the treatment of pain can reduce agitation in people with moderate to severe dementia living in nursing homes.; Design: Cluster randomised controlled trial.; Setting: 60 clusters (single independent nursing home units) in 18 nursing homes within five municipalities of western Norway.; Participants: 352 residents with moderate to […]