Tariot, Pierre, Salloway, Steven, Yardley, Jane, Mackell, Joan, Moline, Margaret

Background: Donepezil (23 mg/day) is approved by the US Food and Drug Administration for the treatment of patients with moderate to severe Alzheimer’s disease (AD). Approval was based on results from a 24-week, randomized, double-blind study of patients who were stable on donepezil 10 mg/day and randomized 2:1 to either increase their donepezil dose to […]

Meeuwsen, Els J., Melis, René J. F., Van Der Aa, Geert C. H. M., Golüke-Willemse, Gertie A. M., De Leest, Benoit J. M., Van Raak, Frank H. J. M., Schölzel-Dorenbos, Carla J M, Verheijen, Desiree C. M., Verhey, Frans R.J., Visser, Marieke C., Wolfs, Claire A., Adang, Eddy M. M., Olde Rikkert, Marcel G. M.

Objective: To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners.; Design: Multicentre randomised controlled trial.; Setting: Nine memory clinics and 159 general practitioners in the Netherlands.; Participants: 175 patients with a new diagnosis of mild to moderate dementia living in the community and their informal […]

Volkers, Karin M., Scherder, Erik J.A.

Background: Physical activity has proven to be beneficial for physical functioning, cognition, depression, anxiety, rest-activity rhythm, quality of life (QoL), activities of daily living (ADL) and pain in older people. The aim of this study is to investigate the effect of walking regularly on physical functioning, the progressive cognitive decline, level of depression, anxiety, rest-activity […]

Voigt-Radloff, Sebastian, Leonhart, Rainer, Rikkert, Marcel Olde, Kessels, Roy, Hüll, Michael

Background: Evidence from pilot trials suggests that structured learning techniques may have positive effects on the performance of cognitive tasks, movement sequences or skills in patients with Alzheimer’s disease. The purpose of this trial is to evaluate whether the usual method of learning by trial and error or the method of errorless learning demonstrate better […]

Faes, Miriam C., Reelick, Miriam F., Melis, René J., Borm, George F., Esselink, Rianne A., Rikkert, Marcel G. Olde

Objective: To assess whether a multifactorial fall prevention program was more effective than usual geriatric care in preventing falls and reducing fear of falling in frail community-dwelling older fallers, with and without cognitive impairment, and in alleviating subjective caregiver burden in caregivers.; Design, Setting, and Participants: A randomized, 2 parallel-group, single-blind, multicenter trial conducted in […]

Nourhashemi, Fati, Andrieu, Sandrine, Gillette-Guyonnet, Sophie, Giraudeau, Bruno, Cantet, Christelle, Coley, Nicola, Vellas, Bruno

Objective: To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer’s disease compared with usual care in memory clinics.; Design: Cluster randomised trial.; Setting: 50 memory clinics in France.; Participants: Patients with Alzheimer’s disease (mini-mental state examination score 12-26). 1131 patients […]

Spijker, Anouk, Verhey, Frans, Graff, Maud, Grol, Richard, Adang, Eddy, Wollersheim, Hub, Vernooij-Dassen, Myrra

Background: Care for people with dementia and their informal caregivers is a challenging aim in healthcare. There is an urgent need for cost-effective support programs that prevent informal caregivers of people with dementia from becoming overburdened, which might result in a delay or decrease of patient institutionalization. For this reason, we have developed the Systematic […]

Schmidt, Reinhold, Baumhackl, Ulf, Berek, Klaus, Brücke, Thomas, Kapeller, Peter, Lechner, Anita, Rainer, Michael, Stögerer, Eva-Maria

We conducted an open, 16-week study on the efficacy of memantine on behavioral disturbances and psychotic symptoms in moderate to moderately severe Alzheimer s disease in daily routine. Fifty-three patients of 20 outpatient centers in Austria were recruited. The Neuropsychiatric Inventory (NPI) was defined as main outcome measure. After 16 weeks the total NPI score […]