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This database contains 21 studies, archived under the term: "agitation"

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The effect of music therapy on reducing agitation in patients with Alzheimer’s disease in Shahryar city nursing home

Objective: One of the most important challenges in present-day societies is the growing number of patients with Alzheimer’s disease and the related problems afflicted upon the patients, their families, and organizations providing health services. Agitation is one of the behavioral problems present in Alzheimer’s. To overcome these behavioral problems, many pharmaceutical and non-pharmaceutical remedies have […]

Longitudinal analysis of differential effects on agitation of a therapeutic wander garden for dementia patients based on ambulation ability

A growth model within the framework of hierarchical linear modeling was used to assess the impact of visiting a wander garden on monthly agitation levels of a group of elderly veterans diagnosed with dementia, with attention to their ambulatory ability. A sample of 34 veterans residing in a locked ward in a dementia unit was […]

Managing agitated behaviour in people with Alzheimer’s disease: The role of live music

Background: Agitation due to Alzheimer’s disease (AD) presents a challenge to occupational therapists working in the older people care sector. Recently background music and music therapy have emerged as promising tools in the management of agitation in AD. This exploratory study investigated whether live music could reduce agitated behaviour in people with AD. Method: A […]

Impact of ambient bright light on agitation in dementia

Objective: To evaluate the effect of ambient bright light therapy (BLT) on agitation among institutionalized persons with dementia. Methods: High intensity, low glare ambient lighting was installed in activity and dining areas of a state psychiatric hospital unit in North Carolina and a dementia-specific residential care facility in Oregon. The study employed a cluster-unit crossover […]

Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)

Background: Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way. Methods: At the first stage of a randomized blinded placebo-controlled trial, 318 patients with Alzheimer disease (AD) with clinically significant agitated behavior were treated in an open […]

Relapse risk after discontinuation of risperidone in Alzheimer’s disease

Background: Among patients with Alzheimer’s disease who have had a response to antipsychotic medication for psychosis or agitation-aggression, the risk of a recurrence of symptoms after discontinuation of the medication has not been established.; Methods: Patients with Alzheimer’s disease and psychosis or agitation-aggression received open-label treatment with risperidone for 16 weeks. Those who had a […]

The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study design

Objectives: : Research studies on the effects of discontinuing antipsychotic medications in patients with dementia have not identified specific target symptoms or response to antipsychotics prior to discontinuation. The Antipsychotic Discontinuation in Alzheimer Disease (ADAD) trial addresses these issues in a randomized, double-blind, placebo-controlled, multicenter risperidone treatment and discontinuation trial. In Phase A, AD patients […]

Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial

Background: A randomized, placebo-controlled clinical trial was undertaken to determine the efficacy of nonpharmacologic individualized interventions (individualized to address unmet needs such as boredom or pain) in decreasing agitation in persons with dementia.; Method: Agitated nursing home residents with advanced dementia (from 9 nursing homes in 5 locations in Maryland, United States) were randomized into […]

A 6-month, randomized, double-blind, placebo-controlled pilot discontinuation trial following response to haloperidol treatment of psychosis and agitation in Alzheimer’s disease

Objective: In patients with Alzheimer’s disease (AD) with psychosis or agitation that respond to haloperidol treatment, to evaluate the risk of relapse following discontinuation.; Methods: In outpatients with AD with symptoms of psychosis or agitation, responders to 20 weeks of haloperidol (0.5-5 mg daily) were randomized to a 24-week, double-blind pilot trial of discontinuation on placebo […]

The effect of staff training on agitation and use of restraint in nursing home residents with dementia: a single-blind, randomized controlled trial

Introduction: Agitation is common in dementia and is associated with use of restraints and use of psychotropic drugs. The aim of this study was to determine whether an education and supervision intervention could reduce agitation and the use of restraints and antipsychotic drugs in nursing homes.; Method: Four Norwegian nursing homes were randomly allocated to […]

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