This database contains 750 studies, archived under the term: "aged, 80 and over"
Click here to filter this large number of results.
Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease
Daiello, Lori A.,
Ott, Brian R.,
Festa, Elena K.,
Friedman, Michael,
Miller, Lindsay A.,
Heindel, William C.
Objective: We conducted a combined observational cohort and case-control study in patients with Alzheimer disease (AD) to assess the effects of acetylcholinesterase inhibitor (ChEI) treatment on cognitive functions important for driving.; Methods: Performance of 24 outpatients with newly diagnosed (untreated) early-stage AD was compared before beginning ChEI (pre-ChEI) and after 3 months of therapy (post-ChEI) […]
The effects of participation in leisure activities on neuropsychiatric symptoms of persons with cognitive impairment: a cross-sectional study
Chiu, Y. C.,
Huang, C. Y.,
Kolanowski, A. M.,
Huang, H. L.,
Shyu, Y. L.,
Lee, S. H.,
Lin, C. R.,
Hsu, W. C.
BACKGROUND: People with cognitive impairment have been shown to engage in few structured activities. During periods of unoccupied time or boredom, these patients most likely manifest neuropsychiatric symptoms. OBJECTIVE: The purposes of this study were to (1) describe the leisure-activity indicators (variety in leisure activities, appraisal of each activity’s restorative function, and leisure dysfunction, i.e. […]
Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design
Pelton, Gregory H.,
Andrews, Howard,
Roose, Steven P.,
Marcus, Sue M.,
D'Antonio, Kristina,
Husn, Hala,
Petrella, Jeffrey R.,
Zannas, Anthony S.,
Doraiswamy, P. Murali,
Devanand, D. P.
Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depression (DOTCODE) pilot clinical trial. The DOTCODE study is the first long-term treatment trial that assesses differences in […]
Vitamin E and memantine in Alzheimer’s disease: clinical trial methods and baseline data
Dysken, Maurice W.,
Guarino, Peter D.,
Vertrees, Julia E.,
Asthana, Sanjay,
Sano, Mary,
Llorente, Maria,
Pallaki, Muralidhar,
Love, Susan,
Schellenberg, Gerard D.,
McCarten, J. Riley,
Malphurs, Julie,
Prieto, Susana,
Chen, Peijun,
Loreck, David J.,
Carney, Sara,
Trapp, George,
Bakshi, Rajbir S.,
Mintzer, Jacobo E.,
Heidebrink, Judith L.,
Vidal-Cardona, Ana,
Arroyo, Lillian M.,
Cruz, Angel R.,
Kowall, Neil W.,
Chopra, Mohit P.,
Craft, Suzanne,
Thielke, Stephen,
Turvey, Carolyn L.,
Woodman, Catherine,
Monnell, Kimberly A.,
Gordon, Kimberly,
Tomaska, Julie,
Vatassery, Govind
Background: Alzheimer’s disease (AD) has been associated with both oxidative stress and excessive glutamate activity. A clinical trial was designed to compare the effectiveness of (i) alpha-tocopherol, a vitamin E antioxidant; (ii) memantine (Namenda), an N-methyl-D-aspartate antagonist; (iii) their combination; and (iv) placebo in delaying clinical progression in AD.; Methods: The Veterans Affairs Cooperative Studies […]
Improving psychotropic drug prescription in nursing home patients with dementia: design of a cluster randomized controlled trial
Smeets, Claudia H. W.,
Smalbrugge, Martin,
Gerritsen, Debby L,
Nelissen-Vrancken, Marjorie H. J. M. G.,
Wetzels, Roland B.,
van der Spek, Klaas,
Zuidema, Sytse U.,
Koopmans, Raymond T. C. M.
Background: Neuropsychiatric symptoms are highly prevalent in nursing home patients with dementia. Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms. This raises questions whether psychotropic drugs are appropriately prescribed. The aim of the PROPER (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia) II […]
V-TIME: a treadmill training program augmented by virtual reality to decrease fall risk in older adults: study design of a randomized controlled trial
Mirelman, Anat,
Rochester, Lynn,
Reelick, Miriam,
Nieuwhof, Freek,
Pelosin, Elisa,
Abbruzzese, Giovanni,
Dockx, Kim,
Nieuwboer, Alice,
Hausdorff, Jeffrey M.
Background: Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while walking forward. Pilot studies suggest that a multi-modal intervention that combines treadmill training to target motor function and a virtual reality […]
Dementia care management: going new ways in ambulant dementia care within a GP-based randomized controlled intervention trial
Eichler, Tilly,
Thyrian, Jochen René,
Dreier, Adina,
Wucherer, Diana,
Kohler, Leonore,
Fiß, Thomas,
Böwing, Georgia,
Michalowsky, Bernhard,
Hoffmann, Wolfgang
Background: Increasing prevalence of dementia is a major challenge for the German healthcare system. The study DelpHi-MV (“Dementia: life- and person-centered help in Mecklenburg-Western Pomerania”) aims to implement and evaluate an innovative subsidiary support system for persons with dementia (PwDs) living at home and their caregivers.; Methods: DelpHi-MV is a GP-based cluster randomized controlled intervention […]
Early detection of memory impairment in people over 65 years old consulting at Health Examination Centers for the French health insurance: the EVATEM protocol
Vannier-Nitenberg, Christiane,
Dauphinot, Virginie,
Bongue, Bienvenu,
Sass, Catherine,
Rouch, Isabelle,
Beauchet, Olivier,
Krolak-Salmon, Pierre,
Fantino, Bruno
Background: Only half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive tests for their predictive ability to diagnose mild cognitive impairments and Alzheimer’s disease and related disorders. For people aged 65 […]