Silverman, Daniel H. S., Geist, Cheri L., Kenna, Heather A., Williams, Katherine, Wroolie, Tonita, Powers, Bevin, Brooks, John, Rasgon, Natalie L.

Differential cerebral metabolic effects of various hormone therapy formulations, and their associations with cognitive status, remain to be established. The principal aim of the current study was to assess relationships between regional cerebral metabolism and estrogen-based hormone therapies. Postmenopausal women (n=53) at elevated risk for Alzheimer’s disease (AD) were on estrogen-containing hormone therapy for at […]

Tierney, Mary C., Oh, Paul, Moineddin, Rahim, Greenblatt, Ellen M., Snow, W. Gary, Fisher, Rory H., Iazzetta, John, Hyslop, Peter St George, MacLusky, Neil J.

We examined whether estradiol and norethindrone hormone therapy (HT) prevented decline in delayed verbal recall in older women with normal to mildly impaired memory functioning. This was a 2-year, randomized, double-blind, placebo-controlled trial of 142 women aged 61-87, randomly assigned to receive 1 mg 17-beta estradiol daily and 0.35 mg norethindrone 3 days/week or daily […]

Black, David S., Cole, Steve W., Irwin, Michael R., Breen, Elizabeth, St. Cyr, Natalie M., Nazarian, Nora, Khalsa, Dharma S., Lavretsky, Helen

Background: Although yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is known about the biological mechanisms mediating such effects. The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression. Methods: Forty-five family dementia […]