Penner, Jacob, Rupsingh, Raul, Smith, Matthew, Wells, Jennie L., Borrie, Michael J., Bartha, Robert

Galantamine is a cholinesterase inhibitor and allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine receptors that is used in the treatment of Alzheimer disease (AD). The purpose of this study was to determine if galantamine treatment would result in detectable hippocampal metabolite changes that correlated with changes in cognition, as measured by the Mini-Mental State Examination […]

Hayashi, Yoshihito, Ishida, Yasushi, Inoue, Teruhiko, Udagawa, Mitsutaka, Takeuchi, Kouzou, Yoshimuta, Hirofumi, Kiue, Kouichirou, Ninomiya, Yoshimasa, Kawano, Jiro, Sameshima, Tetsuro, Kawahara, Takashi, Goto, Isamu, Shudo, Kenji, Kurayama, Shigeki, Nakamura, Jungo, Okahara, Kazunori, Mitsuyama, Yoshio

The efficacy and safety of the kampo medicine Yokukansan (YKS, TJ-54) in the treatment of behavioral and psychological symptoms of dementia (BPSD) were investigated in patients with Alzheimer’s disease (AD) in an open-label study. This study included 26 patients who had been diagnosed as having AD and were not treated with donepezil hydrochloride. These patients […]

Okahara, Kazunori, Ishida, Yasushi, Hayashi, Yoshihito, Inoue, Teruhiko, Tsuruta, Kazuhito, Takeuchi, Kouzou, Yoshimuta, Hirofumi, Kiue, Kouichirou, Ninomiya, Yoshimasa, Kawano, Jiro, Yoshida, Kensei, Noda, Shouji, Tomita, Seiichiro, Fujimoto, Masumi, Hosomi, Jun, Mitsuyama, Yoshio

Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer’s disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on […]