This database contains 25 studies, archived under the term: "Plos One"
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Tea Consumption and Cognitive Impairment: A Cross-Sectional Study among Chinese Elderly
Shen, Wei,
Xiao, Yuanyuan,
Ying, Xuhua,
Li, Songtao,
Zhai, Yujia,
Shang, Xiaopeng,
Li, Fudong,
Wang, Xinyi,
He, Fan,
Lin, Junfen
Background: Laboratorial and epidemiological researches suggested that tea exhibited potential neuroprotective effect which may prevent cognitive impairment, but there were few data among the elderly aged 60 years and above in China.; Objective: The objective was to explore the relationship between characteristics of tea consumption and cognitive impairment.; Design: We analyzed the baseline data from […]
Effectiveness of family meetings for family caregivers on delaying time to nursing home placement of dementia patients: a randomized trial
Joling, Karlijn J,
van Marwijk, Harm W.J.,
van der Horst, Henriëtte E,
Scheltens, Philip,
van de Ven, Peter M.,
Appels, Bregje A.,
van Hout, Hein P.J.
Background: Interventions relieving the burden of caregiving may postpone or prevent patient institutionalization. The objective of this study was to determine whether a family meetings intervention was superior to usual care in postponing nursing home placement of patients with dementia.; Methods: A randomized multicenter trial was conducted among 192 patients with a clinical diagnosis of […]
Efficacy of memantine for agitation in Alzheimer’s dementia: a randomised double-blind placebo controlled trial
Fox, Chris,
Crugel, Monica,
Maidment, Ian,
Auestad, Bjorn Henrik,
Coulton, Simon,
Treloar, Adrian,
Ballard, Clive,
Boustani, Malaz,
Katona, Cornelius,
Livingston, Gill
Background: Agitation in Alzheimer’s disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary […]
Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial
Ballard, Clive,
Jones, Emma,
Gauge, Nathan,
Aarsland, Dag,
Nilsen, Odd Bjarte,
Saxby, Brian K.,
Lowery, David,
Corbett, Anne,
Wesnes, Keith,
Katsaiti, Eirini,
Arden, James,
Amoako, Derek,
Prophet, Nicholas,
Purushothaman, Balaji,
Green, David
Background: The study determined the one year incidence of post operative cognitive decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic intervention in reducing post-operative cognitive impairment in older adults (over 60 years of age) undergoing elective orthopaedic or abdominal surgery.; Methods and Trial Design: The design was a prospective cohort study with a […]
Effect of acupuncture in mild cognitive impairment and Alzheimer disease: a functional MRI study
Wang, Z.,
Nie, B.,
Li, D.,
Zhao, Z.,
Han, Y.,
Song, H.,
Xu, J.,
Shan, B.,
Lu, J.,
Li, K.
We aim to clarify the mechanisms of acupuncture in treating mild cognitive impairment (MCI) and Alzheimer disease (AD) by using functional magnetic resonance imaging (fMRI). Thirty-six right-handed subjects (8 MCI patients, 14 AD patients, and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all the subjects. MRI data acquisition […]
Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial
Zhang, Y.,
Lin, C.,
Zhang, L.,
Cui, Y.,
Gu, Y.,
Guo, J.,
Wu, D.,
Li, Q.,
Song, W.
OBJECTIVES: To explore the efficacy of Chinese herbal formula compared with donepezil 5 mg/day in patients with mild Alzheimer’s disease (AD). METHODS: Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group during the 24-week trial. The outcomes were measured by ADAS-cog, […]
Preventing loss of independence through exercise (PLIE): a pilot clinical trial in older adults with dementia
Barnes, D. E.,
Mehling, W.,
Wu, E.,
Beristianos, M.,
Yaffe, K.,
Skultety, K.,
Chesney, M. A.
BACKGROUND: Current dementia medications have small effect sizes, many adverse effects and do not change the disease course. Therefore, it is critically important to study alternative treatment strategies. The goal of this study was to pilot-test a novel, integrative group exercise program for individuals with mild-to-moderate dementia called Preventing Loss of Independence through Exercise (PLIE), […]
Incidence and prediction of falls in dementia: a prospective study in older people
Background: Falls are a major cause of morbidity and mortality in dementia, but there have been no prospective studies of risk factors for falling specific to this patient population, and no successful falls intervention/prevention trials. This prospective study aimed to identify modifiable risk factors for falling in older people with mild to moderate dementia.; Methods […]