Ozdemir, Leyla, Akdemir, Nuran

Aims: The purpose of this study was to investigate and assess the effects of musical therapy, painting inanimate–animate object pictures, and orientation to time–place–person interventions on the cognitive state, depression, and anxiety levels of mildly-affected Alzheimer’s patients. Methods: The study using a quasi-experimental design was conducted with 27 mildly-affected Alzheimer’s patients. The effects of the […]

Napryeyenko, Oleksandr, Sonnik, Grigoriy, Tartakovsky, Igor

Secondary analyses of a randomised controlled trial were performed to find out whether treatment effects of Ginkgo biloba extract EGb 761® differed by type of dementia. Three hundred ninety-five patients aged 50 years or above, with dementia with neuropsychiatric features were treated with EGb 761® (240 mg/day) or placebo for 22 weeks. Patients scored between […]

Witt, Karsten, Daniels, Christine, Krack, Paul, Volkmann, Jens, Pinsker, Markus O., Kloss, Manja, Tronnier, Volker, Schnitzler, Alfons, Wojtecki, Lars, Bötzel, Kai, Danek, Adrian, Hilker, Rüdiger, Sturm, Volker, Kupsch, Andreas, Karner, Elfriede, Deuschl, Günther

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in Parkinson’s disease (PD). Dementia is considered as a contraindication for STN-DBS. However, no controlled study assessed the impact of STN-DBS on the QoL and motor outcome in PD patients with a borderline global cognitive impairment. We studied clinical baseline […]

Amenta, Francesco, Carotenuto, Anna, Fasanaro, Angiola Maria, Rea, Raffaele, Traini, Enea

Background: Cholinesterase inhibitors (ChE-Is) are among the drugs more largely used for the treatment of mild-to-moderate symptoms of Alzheimer’s disease (AD), but beneficial long-term effects of these compounds on the cognitive, functional, and behavioural symptoms of the disease are small and not always apparent in practice. Preclinical investigations have suggested that association between ChE-Is and […]

Morillas-Ruiz, J. M., Rubio-Perez, J. M., Albaladejo, M. D., Zafrilla, P., Parra, S., Vidal-Guevara, M. L.

Background: A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. Blood levels of homocysteine may be increased in AD and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, plasma total homocysteine (tHcy) concentration may […]

Muresanu, Dafin F., Alvarez, X. Anton, Moessler, Herbert, Novak, Philipp H., Stan, Adina, Buzoianu, Anca, Bajenaru, Ovidiu, Popescu, Bogdan O.

The maintenance of the effects of Cerebrolysin, a peptidergic compound with neurotrophic activity, on cognitive performance and qEEG activity was investigated through a 12-week, open-label extension of a 4-week, randomised, placebo-controlled pilot study. Thirty-three out of 41 patients with mild-to-moderate severe probable vascular dementia (VaD) according to NINDS-AIREN participating in the double-blind phase of the […]

Napryeyenko, Oleksandr, Sonnik, Grigoriy, Tartakovsky, Igor

Secondary analyses of a randomised controlled trial were performed to find out whether treatment effects of Ginkgo biloba extract EGb 761 differed by type of dementia. Three hundred ninety-five patients aged 50 years or above, with dementia with neuropsychiatric features were treated with EGb 761 (240 mg/day) or placebo for 22 weeks. Patients scored between […]

de Oliveira, Fabricio Ferreira, Bertolucci, Paulo Henrique Ferreira, Chen, Elizabeth Suchi, Smith, Marilia de Arruda Cardoso

To evaluate correlations of pharmacological treatment with cognitive and behavioral symptoms in patients with dementia due to Alzheimer’s disease with low schooling, subjects were assessed for demographic features, neuropsychiatric symptoms, cognitive decline, functionality, caregiver burden, APOE haplotypes and pharmacological treatment. Among 217 patients, use of cholinesterase inhibitors with or without Memantine was associated with less […]

Cettomai, Deanna, Kwasa, Judith, Birbeck, Gretchen L., Price, Richard W., Bukusi, Elizabeth A., Meyer, Ana-Claire

Background: Recent efforts to improve neurological care in resource-limited settings have focused on providing training to non-physician healthcare workers.; Methods: A one-day neuro-HIV training module emphasizing HIV-associated dementia (HAD) and peripheral neuropathy was provided to 71 health care workers in western Kenya. Pre- and post-tests were administered to 55 participants.; Results: Mean age of participants […]