Montero-Odasso, Manuel, Muir-Hunter, Susan W., Oteng-Amoako, Afua, Gopaul, Karen, Islam, Anam, Borrie, Michael, Wells, Jennie, Speechley, Mark

Background: Gait deficits are prevalent in people with dementia and increase their fall risk and future disability. Few treatments exist for gait impairment in Alzheimer’s disease (AD) but preliminary studies have shown that cognitive enhancers may improve gait in this population. Objective: To determine the efficacy of donepezil, a cognitive enhancer that improves cholinergic activity, […]

Mitolo, Micaela, Gardini, Simona, Fasano, Fabrizio, Crisi, Girolamo, Pelosi, Annalisa, Pazzaglia, Francesca, Caffarra, Paolo

Spatial abilities decline in normal aging and decrease faster and earlier in Alzheimer’s disease (AD), but these deficits are under investigated. The main goals of this study were to assess visuospatial memory abilities in mild cognitive impairment (MCI), in order to verify whether these tasks might be valid as the standard cognitive test to differentiate […]

Lovestone, Simon, Boadab, Mercè, Dubois, Bruno, Hüll, Michael, Rinne, Juha O., Huppertz, Hans-Jürgen, Calero, Miguel, Andrés, María V., Gómez-Carrillo, Belén, Leon, Teresa, del Seri, Teodoro

Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of an inhibitor of glycogen synthase kinase-3 (GSK-3), in AD. Methods: Mild to moderate (Mini-Mental State Examination (MMSE) score, 14–26) AD patients on cholinesterase inhibitor and/or memantine treatment […]

Engvig, Andreas, Fjell, Anders M., Westlye, Lars T., Skaane, Nina V., Dale, Anders M., Holland, Dominic, Due-Tønnessen, Paulina, Sundseth, Øyvind, Walhovd, Kristine B.

Subjective memory impairment (SMI) is a common risk factor for Alzheimer’s disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy in 19 memory clinic patients with SMI. We used a sensitive longitudinal magnetic resonance imaging protocol and compared the patients with 42 […]

Claxton, Amy, Baker, Laura D., Hanson, Angela, Trittschuh, Emily H., Cholerton, Brenna, Morgan, Amy, Callaghan, Maureen, Arbuckle, Matthew, Behl, Colin, Craft, Suzanne

[Correction Notice: An Erratum for this article was reported in Vol 45(4) of Journal of Alzheimer’s Disease (see record [rid]2015-17286-023[/rid]). In the original article, Tables 1 and 2 were missing. Tables 1 and 2 are present in the erratum.] Previous trials have shown promising effects of intranasally administered insulin for adults with Alzheimer’s disease dementia […]

Bondi, Mark W., Edmonds, Emily C., Jak, Amy J., Clark, Lindsay R., Delano-Wood, Lisa, McDonald, Carrie R., Nation, Daniel A., Libon, David J., Au, Rhoda, Galasko, Douglas, Salmon, David P.

We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward by Jak and Bondi designed to balance sensitivity and reliability. 1,150 ADNI participants were diagnosed at baseline as cognitively normal (CN) or MCI via ADNI criteria […]