This database contains 39 studies, archived under the term: "Dementia And Geriatric Cognitive Disorders"
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Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer’s disease: the OmegAD study
Freund-Levi, Yvonne,
Hjorth, Erik,
Lindberg, Catharina,
Cederholm, Tommy,
Faxén-Irving, Gerd,
Vedin, Inger,
Palmblad, Jan,
Wahlund, Lars-Olof,
Schultzberg, Marianne,
Basun, Hans,
Eriksdotter-Jönhagen, Maria
Background: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer’s disease (AD).; Objective: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.; Methods: Thirty-five patients (70.3 +/- 8.2 years) […]
Long-term safety and efficacy of donepezil in patients with severe Alzheimer’s disease: results from a 52-week, open-label, multicenter, extension study in Japan
Homma, Akira,
Imai, Yukimichi,
Tago, Hisao,
Asada, Takashi,
Shigeta, Masahiro,
Iwamoto, Toshihiko,
Takita, Masashi,
Arimoto, Itaru,
Koma, Hiroshi,
Takase, Takao,
Ohbayashi, Toshio
Background/aims: A 6-month, randomized, double-blind, placebo-controlled study was extended to evaluate long-term safety and efficacy of donepezil in community-dwelling Japanese patients with severe Alzheimer’s disease (AD).; Methods: 189 patients were enrolled from the double-blind study into a 52-week, open-label extension study. After a 2- to 8-week washout, donepezil was escalated within 6 weeks to 10 […]
Rosiglitazone monotherapy in mild-to-moderate Alzheimer’s disease: results from a randomized, double-blind, placebo-controlled phase III study
Gold, Michael,
Alderton, Claire,
Zvartau-Hind, Marina,
Egginton, Sally,
Saunders, Ann M.,
Irizarry, Michael,
Craft, Suzanne,
Landreth, Gary,
Linnamägi, Ulla,
Sawchak, Sharon
Background/aims: A phase II study of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone extended release (RSG XR) in mild-to-moderate Alzheimer’s disease (AD) detected a treatment benefit to cognition in apolipoprotein E(APOE)-ε4-negative subjects. The current phase III study with prospective stratification by APOE genotype was conducted to confirm the efficacy and safety of RSG XR in mild-to-moderate […]
Adaptive cognitive testing in cerebrovascular disease and vascular dementia
Wouters, Hans,
de Koning, Inge,
Zwinderman, Aeilko H.,
van Gool, Willem A.,
Schmand, Ben,
Buiter, Maarten,
Lindeboom, Robert
Background/aims: To examine whether brevity can be combined with precision in measuring global cognitive ability in patients with cerebrovascular disease (CVD) or vascular dementia (VaD). Longer tests (e.g. the CAMCOG) are precise but inefficient, whereas brief tests (e.g. the MMSE) are efficient but imprecise.; Methods: A simulated computerized adaptive testing (CAT) algorithm using existing CAMCOG […]
Validity of the Mattis Dementia Rating Scale to detect mild cognitive impairment in Parkinson’s disease and REM sleep behavior disorder
Villeneuve, Sylvia,
Rodrigues-Brazète, Jessica,
Joncas, Steve,
Postuma, Ronald B.,
Latreille, Véronique,
Gagnon, Jean-François
Background/aims: Mild cognitive impairment (MCI) is frequent in Parkinson’s disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State […]
Cost analysis of early psychosocial intervention in Alzheimer’s disease
Søgaard, Rikke,
Sørensen, Jan,
Waldorff, Frans B.,
Eckermann, Ane,
Buss, Dorthe V.,
Waldemar, Gunhild
Background/aim: To investigate the impact of early psychosocial intervention aimed at patients with Alzheimer’s disease (AD) and their caregivers on resource use and costs from a societal perspective.; Methods: Dyads of patients and their primary caregiver were randomised to intervention (n = 163) or control (n = 167) and followed for 3 years. Health care […]
Clock drawing in the Montreal Cognitive Assessment: recommendations for dementia assessment
Price, Catherine C.,
Cunningham, Holly,
Coronado, Nicole,
Freedland, Alana,
Cosentino, Stephanie,
Penney, Dana L.,
Penisi, Alfio,
Bowers, Dawn,
Okun, Michael S.,
Libon, David J.
Background: Clock drawing is part of the Montreal Cognitive Assessment (MoCA) test but may have administration and scoring limitations. We assessed (1) the reliability of the MoCA clock criteria relative to a published error scoring approach, (2) whether command-only administration could distinguish dementia from cognitively intact individuals and (3) the value of adding a clock […]