ASPREE Investigator Group,

Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals. Our primary hypothesis is that daily oral 100 mg enteric-coated aspirin will extend a composite […]

Vidoni, Eric D., Van Sciver, Angela, Johnson, David K., He, Jinghua, Honea, Robyn, Haines, Brian, Goodwin, Jami, Laubinger, M. Pat, Anderson, Heather S., Kluding, Patricia M., Donnelly, Joseph E., Billinger, Sandra A., Burns, Jeffrey M.

The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. […]

Pelton, Gregory H., Andrews, Howard, Roose, Steven P., Marcus, Sue M., D'Antonio, Kristina, Husn, Hala, Petrella, Jeffrey R., Zannas, Anthony S., Doraiswamy, P. Murali, Devanand, D. P.

Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depression (DOTCODE) pilot clinical trial. The DOTCODE study is the first long-term treatment trial that assesses differences in […]

Tremont, Geoffrey, Davis, Jennifer, Papandonatos, George D., Grover, Christine, Ott, Brian R., Fortinsky, Richard H., Gozalo, Pedro, Bishop, Duane S.

Family caregivers of individuals with dementia are at heightened risk for emotional and mental health problems. Many caregivers do not seek assistance or become isolated in their caregiving role. Multi-component interventions have demonstrated efficacy for reducing emotional distress and burden, although these approaches are potentially costly and are not widely accessible. In response to these […]