This database contains 477 studies, archived under the term: "Non-pharmacological Treatment"
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Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved […]
Qualitative analysis of therapeutic light effects on global function in Alzheimer’s disease
The occurrence of Alzheimer’s disease (AD) is growing, with 68% of cases occurring in women. Declines in global function exacerbated by reversal of day-night patterns, disturbed sleep-wake rhythms, and excessive daytime sleepiness make managing AD difficult. In this study, the authors examined the effect and duration of effect of therapeutic light on sleep, rest-activity, and […]
Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer’s disease: results of a randomized, controlled trial
McCurry, Susan M.,
Pike, Kenneth C.,
Vitiello, Michael V.,
Logsdon, Rebecca G.,
Larson, Eric B.,
Teri, Linda
Objectives: To test the effects of walking, light exposure, and a combination intervention (walking, light, and sleep education) on the sleep of persons with Alzheimer’s disease (AD).; Design: Randomized, controlled trial with blinded assessors.; Setting: Independent community living.; Participants: One hundred thirty-two people with AD and their in-home caregivers.; Interventions: Participants were randomly assigned to […]
Effectiveness of group music intervention against agitated behavior in elderly persons with dementia
Lin, Yu,
Chu, Hsin,
Yang, Chyn-Yng,
Chen, Chiung-Hua,
Chen, Shyi-Gen,
Chang, Hsiu-Ju,
Hsieh, Chia-Jung,
Chou, Kuei-Ru
Objectives: This study explored the effectiveness of group music intervention against agitated behavior in elderly persons with dementia.; Methods: This was an experimental study using repeated measurements. Subjects were elderly persons who suffered from dementia and resided in nursing facilities. In total, 104 participants were recruited by permuted block randomization and of the 100 subjects […]
Study protocol for the recreational stimulation for elders as a vehicle to resolve delirium superimposed on dementia (Reserve For DSD) trial
Kolanowski, Ann M.,
Fick, Donna M.,
Litaker, Mark S.,
Clare, Linda,
Leslie, Doug,
Boustani, Malaz
Background: Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mechanisms involved in its etiology are not […]
Pilot study of a nonpharmacological intervention for delirium superimposed on dementia
Kolanowski, Ann M.,
Fick, Donna M.,
Clare, Linda,
Steis, Melinda,
Boustani, Malaz,
Litaker, Mark
Delirium is a common neuropsychiatric syndrome that occurs most frequently in older adults with dementia and is referred to as delirium superimposed on dementia (DSD). Our aim in this pilot project was to demonstrate that implementation of cognitively stimulating activities is clinically feasible and has potential to reduce delirium severity and duration and functional loss […]
A randomized clinical trial of theory-based activities for the behavioral symptoms of dementia in nursing home residents
Kolanowski, Ann,
Litaker, Mark,
Buettner, Lin,
Moeller, Joyel,
Costa, Paul T., Jr.
Objectives: To test the main and interactive effects of activities derived from the Need-Driven Dementia-Compromised Behavior model for responding to behavioral symptoms in nursing home residents.; Design: Randomized double-blind clinical trial.; Setting: Nine community-based nursing homes.; Participants: One hundred twenty-eight cognitively impaired residents randomly assigned to activities adjusted to functional level (FL) (n=32), personality style […]