This database contains 162 studies, archived under the term: "Diagnostic Target Identification"
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Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates
Bondi, Mark W.,
Edmonds, Emily C.,
Jak, Amy J.,
Clark, Lindsay R.,
Delano-Wood, Lisa,
McDonald, Carrie R.,
Nation, Daniel A.,
Libon, David J.,
Au, Rhoda,
Galasko, Douglas,
Salmon, David P.
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward by Jak and Bondi designed to balance sensitivity and reliability. 1,150 ADNI participants were diagnosed at baseline as cognitively normal (CN) or MCI via ADNI criteria […]
Predicting decline in mild cognitive impairment: A prospective cognitive study
Objective: The primary aim of this study was to identify cognitive tests that differentiate between persons with mild cognitive impairment (MCI) who later develop cognitive decline and those who remain stable. Method: This study used a prospective longitudinal design. One hundred twenty-two older adults with single-domain or multiple-domain amnestic MCI were recruited from memory clinics. […]
A brief neuropsychological battery for use in the chronic heart failure population
Bauer, Lisa,
Pozehl, Bunny,
Hertzog, Melody,
Johnson, Julene,
Zimmerman, Lani,
Filipi, Mary
Background: Cognitive impairment is a recognized consequence of heart failure; however, there are no neuropsychological batteries with documented psychometric data in the chronic heart failure population.; Aims: To document the psychometric properties of a brief neuropsychological battery in a chronic heart failure sample.; Methods: The Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making […]
Hostility and change in cognitive function over time in older blacks and whites
Barnes, Lisa L.,
Mendes de Leon, Carlos F.,
Bienias, Julia L.,
Wilson, Robert S.,
Everson-Rose, Susan A.,
Evans, Denis A.
Objective: To test whether the level of hostility predicted the rate of cognitive decline in a community of older blacks and whites and whether the association varied as a function of race.; Methods: Over 4800 persons from a defined community in Chicago completed up to three structured interviews at approximately 3 year intervals over a […]
The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer’s disease
Bahl, Justyna Maria Czarna,
Heegaard, Niels H.H.,
Falkenhorst, Gerhard,
Laursen, Henning,
Høgenhaven, Hans,
Mølbak, Kåre,
Jespersgaard, Cathrine,
Hougs, Lotte,
Waldemar, Gunhild,
Johannsen, Peter,
Christiansen, Michael
Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer’s […]
Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests
Bahar-Fuchs, Alex,
Villemagne, Victor,
Ong, Kevin,
Chetélat, Gaël,
Lamb, Fiona,
Reininger, Cornelia B.,
Woodward, Michael,
Rowe, Christopher C.
Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of […]
Measuring memory in large group settings using a continuous recognition test
Memory function generally deteriorates with age, and memory impairments are a common symptom of serious illness such as dementia. Although screening tests are widely used throughout Medicine, they are not yet commonly used to detect memory impairments. The objective of this study was to characterize an audience-based memory test suitable for administration to a large […]
What predicts cognitive decline in de novo Parkinson’s disease?
Arnaldi, Dario,
Campus, Claudio,
Ferrara, Michela,
Famà, Francesco,
Picco, Agnese,
De Carli, Fabrizio,
Accardo, Jennifer,
Brugnolo, Andrea,
Sambuceti, Gianmario,
Morbelli, Silvia,
Nobili, Flavio
Subtle cognitive impairment can be detected in early Parkinson’s disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess which clinical, neuropsychological, and functional neuroimaging (dopamine transporter [DAT] and perfusion single photon emission computed tomography [SPECT]) characteristics at baseline was predictive of cognitive decline during an […]
The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer’s disease
This study investigated the neuropsychological hallmarks of posterior cortical atrophy (PCA). Seventeen patients with PCA, 17 patients with probable Alzheimer’s disease (PAD), and 17 healthy age-matched subjects underwent neuropsychological testing for abstract reasoning, visuospatial abilities, memory, language, executive functions, praxes, and attention. The PCA patients were significantly more impaired in visual perception, spatial memory, visual […]