Lovestone, Simon, Boadab, Mercè, Dubois, Bruno, Hüll, Michael, Rinne, Juha O., Huppertz, Hans-Jürgen, Calero, Miguel, Andrés, María V., Gómez-Carrillo, Belén, Leon, Teresa, del Seri, Teodoro

Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of an inhibitor of glycogen synthase kinase-3 (GSK-3), in AD. Methods: Mild to moderate (Mini-Mental State Examination (MMSE) score, 14–26) AD patients on cholinesterase inhibitor and/or memantine treatment […]

Fernández-Calvo, Bernardino, Contador, Israel, Serna, Adriana, de Lucena, Virginia Menezes, Ramos, Francisco

The study aimed to verify whether the format of an individual or group intervention, applied in a multimodal cognitive stimulation program (MCSP), had an impact on progression and behavioral disturbances associated with Alzheimer’s disease patients (AD). Forty-five participants diagnosed with probable AD were randomly divided into 3 groups. The performance of both experimental groups, receiving […]

Emre, Murat, Poewe, Werner, De Deyn, Peter Paul, Barone, Paolo, Kulisevsky, Jaime, Pourcher, Emmanuelle, van Laar, Teus, Storch, Alexander, Micheli, Federico, Burn, David, Durif, Frank, Pahwa, Rajesh, Callegari, Francesca, Tenenbaum, Nadia, Strohmaier, Christine

Objective: This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.; Methods: This was a 76-week, prospective, open-label, randomized study in patients aged 50 to 85 years. Primary outcomes included incidence of, and discontinuation due to, predefined […]

Díaz-Veiga, Pura, Sancho, Mayte, García, Álvaro, Rivas, Esther, Abad, Elixabet, Suárez, Nerea, Mondragón, Gabriela, Buiza, Cristina, Orbegozo, Ana, Yanguas, Javier

Introduction: The Model of Person Centered Care has attracted increasing interest for use in gerontology centers. Therefore, the contributions about its impact are scarce in our context. The objective of this paper is to establish the impact that the interventions associated with the Model of Person Centered Care in the «Etxean Ondo» Project have on […]

Carrasco, Manuel Martin, Agüera, Luis, Gil, Pedro, Moríñigo, Angel, Leon, Teresa

The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to […]

Bermejo-Pareja, Félix, Benito-León, Julián, Louis, Elan D., Trincado, Rocío, Carro, Eva, Villarejo, Alberto, de la Cámara, Agustín Gómez

Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]

Benito-León, J., Mitchell, A. J., Hernández-Gallego, J., Bermejo-Pareja, F.

Background and Purpose: Studies of high body mass index (BMI) and cognition in the elderly have shown conflicting results. While some studies have shown a detrimental effect of high BMI on cognitive function, others have observed beneficial effects on cognition. Our aim was to assess cognitive function in a large population-based sample of overweight (BMI […]