This database contains 57 studies, archived under the term: "Spain"
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The efficacy of nonpharmacological treatment for dementia-related apathy
Ferrero-Arias, Julio,
Goñi-Imízcoz, Miguel,
González-Bernal, Jerónimo,
Lara-Ortega, Fernando,
da Silva-González, Alvaro,
Díez-Lopez, Mateo
Objective: To determine the usefulness of a formal, structured, nonpharmacological treatment for apathetic dementia patients.; Patients and Methods: A controlled, cross-over, randomized, simple-blind, multicentre clinical trial. A total of 146 institutionalized or day care dementia patients with a stage 1 or 2 Clinical Dementia Rating, with no significant motor or sensory problems, or with rapidly […]
Pridopidine for the treatment of motor function in patients with Huntington’s disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
de Yebenes, Justo Garcia,
Landwehrmeyer, Bernhard,
Squitieri, Ferdinando,
Reilmann, Ralf,
Rosser, Anne,
Barker, Roger A,
Saft, Carsten,
Magnet, Markus K.,
Sword, Alastair,
Rembratt, Åsa,
Tedroff, Joakim
Background: Huntington’s disease is a progressive neurodegenerative disorder, characterised by motor, cognitive, and behavioural deficits. Pridopidine belongs to a new class of compounds known as dopaminergic stabilisers, and results from a small phase 2 study in patients with Huntington’s disease suggested that this drug might improve voluntary motor function. We aimed to assess further the […]
Combination treatment in Alzheimer’s disease: results of a randomized, controlled trial with cerebrolysin and donepezil
Alvarez, X. Anton,
Cacabelos, R.,
Sampedro, C.,
Couceiro, V.,
Aleixandre, M.,
Vargas, M.,
Linares, C.,
Granizo, E.,
García-Fantini, M.,
Baurecht, W.,
Doppler, E.,
Moessler, H.
Treatment with neurotrophic agents might enhance and/or prolong the effects of cholinesterase inhibitors (ChEIs) in Alzheimer’s disease (AD). We compared the safety and efficacy of the neurotrophic compound Cerebrolysin (10 ml; n=64), donepezil (10 mg; n=66) and a combination of both treatments (n=67) in mild-to-moderate (mini-mental state examination-MMSE score 12-25) probable AD patients enrolled in […]
Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer’s disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin
Alvarez, X. A.,
Cacabelos, R.,
Sampedro, C.,
Aleixandre, M.,
Linares, C.,
Granizo, E.,
Doppler, E.,
Moessler, H.
Background: cerebrolysin is a neuropeptide preparation mimicking the effects of neurotrophic factors. This subgroup analysis assessed safety and efficacy of Cerebrolysin in patients with moderate to moderately severe Alzheimer’s disease (AD) (ITT data set: N = 133; MMSE: 14-20) included in a dose-finding study (ITT data set: N = 51; MMSE: 14-25). Results of the […]
Effectiveness of an intervention in groups of family caregivers of dependent patients for their application in primary health centers. Study protocol
Rodriguez-Sánchez, Emiliano,
Mora-Simón, Sara,
Porras-Santos, Nieves,
Patino-Alonso, María C.,
Recio-Rodríguez, José I,
Becerro-Muñoz, Concepción,
Pérez-Arechaederra, Diana,
Gómez-Marcos, Manuel A,
García-Ortiz, Luis
Background: Although Primary Health Care (PHC) Teams are used to deal with prevention and treatment of sanitary problems in adults with chronic diseases, they usually have a lack of experience in development of psychotherapeutic interventions. However, these interventions are the ones that achieve better results to reduce symptomatology and improve emotional state of caregivers.The study […]
EDUCA study: Psychometric properties of the Spanish version of the Zarit Caregiver Burden Scale
Martin-Carrasco, M.,
Otermin, P.,
Pérez-Camo, V.,
Pujol, J.,
Agüera, L.,
Martín, M. J.,
Gobartt, A. L.,
Pons, S.,
Balañá, M.
Objectives: The Zarit Caregiver Burden Scale, translated and validated into Spanish, is sensitive to the application of a Psychoeducational Intervention Program (PIP) for the prevention and reduction of burden in caregivers of Alzheimer’s disease (AD) patients (EDUCA study). The data obtained in EDUCA was used to reanalyse its psychometric properties and the cut-off points of […]
The effect of donepezil in comparison with conventional treatment on cognitive functioning and the performance of the patient in a prospective cohort of patients with Alzheimer’s disease treated in routine clinical practice in Spain
López-Pousa, S.,
Bermejo-Pareja, F.,
Frank, A.,
Hernández, F.,
León, T.,
Rejas-Gutiérrez, J.
Aims: Our aim was to perform a secondary analysis of a 12-month-long, non-blind, multi-centre prospective cost-of-illness study. The analysis assessed the effect of donepezil on cognitive functioning and the performance of patients with possible or probable Alzheimer’s disease, compared to that of other drugs for dementia.; Patients and Methods: A sample of 700 patients took […]
Health and nutritional promotion program for patients with dementia (NutriAlz Study): design and baseline data
Salva, A.,
Andrieu, S.,
Fernandez, E.,
Schiffrin, E. J.,
Moulin, J.,
Decarli, B.,
Guigoz, Y.,
Vellas, B.
Background: There is a lack of data on global weight loss prevention programs for patients with dementia or clear evidence about their impact on a functional level, caregiver burden or the use of healthcare and social resources. NutriAlz is a socio-educative and nutritional intervention program to prevent weight loss and loss of function in dementia […]