This database contains 71 studies, archived under the term: "Japan"
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Study of the voxel-based specific regional analysis system for Alzheimer’s disease imaging sequence after magnetic resonance apparatus replacement
Tsukagoshi, Yuki,
Kanai, Yoshihiro,
Yasui, Gou,
Abe, Yuuji,
Maemura, Keisuke,
Nakazawa, Masaki,
Yamaji, Yuugo,
Mihara, Ban
In our institute, an MR apparatus, MAGNETOM VISION (Siemens) was replaced by ECHELON Vega (HITACHI). Z-score data acquired by MPRAGE (VISION) was compared with those by radio frequency-spoiled steady-state acquisition with rewinded gradient echo (RSSG) and gradient echo inversion recovery (GEIR) (ECHELON). For this study, ten normal volunteers were recruited and their data ware obtained […]
Efficacy and tolerability of risperidone, yokukansan, and fluvoxamine for the treatment of behavioral and psychological symptoms of dementia: a blinded, randomized trial
Teranishi, Mika,
Kurita, Masatake,
Nishino, Satoshi,
Takeyoshi, Kenji,
Numata, Yukio,
Sato, Tadahiro,
Tateno, Amane,
Okubo, Yoshiro
The descriptive term behavioral and psychological symptoms of dementia (BPSD) is used to cover a range of noncognitive disturbances including anxiety, depression, irritability, aggression, agitation, eating disorders, and inappropriate social or sexual behaviors. Behavioral and psychological symptoms of dementia are seen in about 90% of patients with dementia. We aimed to compare the efficacy and […]
Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion imaging in mild Alzheimer’s disease
Terada, Seishi,
Sato, Shuhei,
Honda, Hajime,
Kishimoto, Yuki,
Takeda, Naoya,
Oshima, Etsuko,
Yokota, Osamu,
Uchitomi, Yosuke
Background: The Wisconsin Card Sorting Test (WCST) has long been used to investigate deficits in executive function in humans. The majority of studies investigating deficient WCST performance focused on the number of categories achieved (CA) and the number of perseverative errors of the Nelson type (PEN). However, there is insufficient evidence that these two measures […]
Impaired glucose metabolism slows executive function independent of cerebral ischemic lesions in Japanese elderly: the Takahata study
Takahashi, Yoshimi,
Iseki, Chifumi,
Wada, Manabu,
Momma, Tadasuke,
Ueki, Masao,
Kawanami, Toru,
Daimon, Makoto,
Suzuki, Kyoko,
Tamiya, Gen,
Kato, Takeo
Objective: Age is known to influence the risk of both cerebral ischemic lesions and impaired cognitive function. Diabetes mellitus (DM) can also be associated with cognitive impairment. However, there has been no study of neuropsychological performance in association with glucose metabolism status and cerebral ischemic lesions in same-aged, community-dwelling elderly persons. The present study was […]
A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment
Suzuki, Takao,
Shimada, Hiroyuki,
Makizako, Hyuma,
Doi, Takehiko,
Yoshida, Daisuke,
Ito, Kengo,
Shimokata, Hiroshi,
Washimi, Yukihiko,
Endo, Hidetoshi,
Kato, Takashi
Background: To examine the effect of multicomponent exercise program on memory function in older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of cognitive functions.; Methodology/principal Findings: Subjects were 100 older adults (mean age, 75 years) with MCI. The subjects were classified to an amnestic MCI group (n = 50) with neuroimaging measures, […]
Physical and psychological effects of 6-week tactile massage on elderly patients with severe dementia
Suzuki, M.,
Tatsumi, A.,
Otsuka, T.,
Kikuchi, K.,
Mizuta, A.,
Makino, K.,
Kimoto, A.,
Fujiwara, K.,
Abe, T.,
Nakagomi, T.,
Hayashi, T.,
Saruhara, T.
Tactile massage is a soft massage that improves physical relaxation and psychological well-being. The purpose of this study was to clarify the effects of a 6-week tactile massage on changes in physical and mental function, symptoms of behavioral and psychological symptoms of dementia (BPSD) among elderly patients with dementia. In addition, chromogranin A (CgA) levels […]
Yokukansan treatment of chronic renal failure patients receiving hemodialysis, with behavioral and psychological symptoms of dementia: an open-label study
Sumiyoshi, Hidenori,
Mantani, Akio,
Nishiyama, Satoshi,
Fujiwaki, Soh,
Ohta, Shoichiro,
Masuda, Yoshikazu,
Tomita, Youhei,
Tarumoto, Naofumi,
Yamawaki, Shigeto
Objective: The efficacy and safety of yokukansan (YKS) for chronic renal failure (CRF) patients receiving hemodialysis with behavioral and psychological symptoms of dementia (BPSD) was evaluated.; Methods: Twelve CRF patients receiving hemodialysis with BPSD were recruited and 7.5 g of YKS powder was added to ongoing therapy with antipsychotics. Neuropsychiatric Inventory (NPI) criteria and Barthel […]