This database contains 100 studies, archived under the term: "Germany"
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Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
Teipel, Stefan J.,
Reuter, Sigrid,
Stieltjes, Bram,
Acosta-Cabronero, Julio,
Ernemann, Ulrike,
Fellgiebel, Andreas,
Filippi, Massimo,
Frisoni, Giovanni,
Hentschel, Frank,
Jessen, Frank,
Klöppel, Stefan,
Meindl, Thomas,
Pouwels, Petra J.W.,
Hauenstein, Karl-Heinz,
Hampel, Harald
Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]
The Nottingham Health Profile: a feasible questionnaire for nursing home residents?
Background: The Nottingham Health Profile (NHP) assesses perceived emotional, social, and physical health problems and the extent to which such problems affect daily activities. The objective of our study was to determine the feasibility of the NHP for nursing home residents.; Methods: A prospective multicenter observational study was conducted in 11 nursing homes from April […]
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years
Stoeck, K.,
Sanchez-Juan, P.,
Gawinecka, J.,
Green, A.,
Ladogana, A.,
Pocchiari, M.,
Sanchez-Valle, R.,
Mitrova, E.,
Sklaviadis, T.,
Kulczycki, J.,
Slivarichova, D.,
Saiz, A.,
Calero, M.,
Knight, R.,
Aguzzi, A.,
Laplanche, J.-L.,
Peoc'h, K.,
Schelzke, G.,
Karch, A.,
van Duijn, C. M.,
Zerr, I.
To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt-Jakob disease cases. However, one special point of criticism of 14-3-3 testing is the specificity in the differential diagnosis of rapid dementia. The constant observation of increased cerebrospinal fluid referrals in the national surveillance centres over the last […]
ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients
Steinacker, Petra,
Klafki, Hans,
Lehnert, Stefan,
Jesse, Sarah,
Arnim, Christine A. F. V.,
Tumani, Hayrettin,
Pabst, Alice,
Kretzschmar, Hans A.,
Wiltfang, Jens,
Otto, Markus
The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be supported by several biochemical markers in cerebrospinal fluid (CSF) such as 14-3-3 proteins and tau protein. Unfortunately, none of the currently known markers are suited for screening or seems to be directly related to the pathophysiological process. A marker fulfilling these criteria might facilitate the early […]
Effects of a low-volume, nutrient- and energy-dense oral nutritional supplement on nutritional and functional status: a randomized, controlled trial in nursing home residents
Stange, Inken,
Bartram, Matthias,
Liao, Yuye,
Poeschl, Karin,
Kolpatzik, Sarah,
Uter, Wolfgang,
Sieber, Cornel C.,
Stehle, Peter,
Volkert, Dorothee
Objectives: Although oral nutritional supplements (ONS) are known to be effective to treat malnutrition in the elderly, evidence from nursing home populations, including individuals with dementia, is rare, especially with regard to functionality and well-being. A known barrier for ONS use among elderly is the volume that needs to be consumed, resulting in low compliance […]
Dual-task performances can be improved in patients with dementia: a randomized controlled trial
Background: Deficits in attention-related cognitive performance measured as dual-task performance represent early markers of dementia and are associated with motor deficits and increased risk of falling. The purpose of this study was to examine the effect of a specific dual-task training in patients with mild to moderate dementia.; Methods: Sixty-one geriatric patients with confirmed dementia […]
Improvements in gait characteristics after intensive resistance and functional training in people with dementia: a randomised controlled trial
Schwenk, Michael,
Zieschang, Tania,
Englert, Stefan,
Grewal, Gurtej,
Najafi, Bijan,
Hauer, Klaus
Background: Preventing and rehabilitating gait disorders in people with dementia during early disease stage is of high importance for staying independent and ambulating safely. However, the evidence gathered in randomized controlled trials (RCTs) on the effectiveness of exercise training for improving spatio-temporal gait parameters in people with dementia is scarce. The aim of the present […]
An intensive exercise program improves motor performances in patients with dementia: translational model of geriatric rehabilitation
Schwenk, Michael,
Dutzi, Ilona,
Englert, Stefan,
Micol, William,
Najafi, Bijan,
Mohler, Jane,
Hauer, Klaus
Background: Translation of intensive exercise programs developed specifically for patients with dementia into clinical settings is lacking.; Objective: To determine if a progressive resistance and functional training program, previously evaluated in dementia outpatients, can be implemented in a geriatric inpatient setting in order to improve motor performances in patients with dementia.; Methods: Eligible patients in […]