This database contains 90 studies, archived under the term: "Australia"
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Use of the Tailored Activities Program to reduce neuropsychiatric behaviors in dementia: an Australian protocol for a randomized trial to evaluate its effectiveness
O'Connor, C. M.,
Clemson, L.,
Brodaty, H.,
Jeon, Y. H.,
Mioshi, E.,
Gitlin, L. N.
Background: Behavioral and psychological symptoms of dementia (BPSD) are often considered to be the greatest challenge in dementia care, leading to increased healthcare costs, caregiver burden, and placement into care facilities. With potential for pharmacological intervention to exacerbate behaviors or even lead to mortality, the development and rigorous testing of non-pharmacological interventions is vital. A […]
Effect of rhythmic auditory cueing on gait in people with Alzheimer disease
Objective: To determine whether rhythmic music and metronome cues alter spatiotemporal gait measures and gait variability in people with Alzheimer disease (AD).; Design: A repeated-measures study requiring participants to walk under different cueing conditions.; Setting: University movement laboratory.; Participants: Of the people (N=46) who met study criteria (a diagnosis of probable AD and ability to […]
The long-term efficacy and tolerability of donepezil in patients with vascular dementia
Wilkinson, David,
Róman, Gustavo,
Salloway, Stephen,
Hecker, Jane,
Boundy, Karyn,
Kumar, Dinesh,
Posner, Holly,
Schindler, Rachel
Objective: To determine the long-term tolerability and efficacy of donepezil in patients with vascular dementia (VaD).; Methods: International, multicentre, open-label, 30-week extension study of two 24-week, randomised, double-blind, placebo-controlled studies. Participants were ambulatory adults (59% female; mean age, 74.7 +/- 0.3) with a diagnosis of possible or probable VaD and without a diagnosis of Alzheimer’s […]
A feasibility study and pilot randomised trial of a tailored prevention program to reduce falls in older people with mild dementia
Wesson, Jacqueline,
Clemson, Lindy,
Brodaty, Henry,
Lord, Stephen,
Taylor, Morag,
Gitlin, Laura,
Close, Jacqueline
Background: People with dementia have a disproportionately high rate of falls and fractures and poorer outcomes, yet there is currently no evidence to guide falls prevention in this population.; Methods: A randomised trial design was used to test feasibility of study components and acceptability of a home hazard reduction and balance and strength exercise fall […]
A randomized crossover trial to study the effect of personalized, one-to-one interaction using Montessori-based activities on agitation, affect, and engagement in nursing home residents with Dementia
van der Ploeg, Eva S,
Eppingstall, Barbara,
Camp, Cameron J.,
Runci, Susannah J.,
Taffe, John,
O'Connor, Daniel W.
Background: Increasingly more attention has been paid to non-pharmacological interventions as treatment of agitated behaviors that accompany dementia. The aim of the current study is to test if personalized one-to-one interaction activities based on Montessori principles will improve agitation, affect, and engagement more than a relevant control condition.; Methods: We conducted a randomized crossover trial […]
The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study
Trollor, Julian N.,
Smith, Evelyn,
Agars, Emmeline,
Kuan, Stacey A.,
Baune, Bernhard T.,
Campbell, Lesley,
Samaras, Katherine,
Crawford, John,
Lux, Ora,
Kochan, Nicole A.,
Brodaty, Henry,
Sachdev, Perminder
Inflammation may contribute to cognitive decline and dementia. This study examined the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor, serum amyloid A, tumour necrosis factor-α and vascular adhesion molecule-1) and cognitive function in 873 non-demented community-dwelling elderly participants aged 70-90 years. Regression analyses were performed […]
An evaluation of dog-assisted therapy for residents of aged care facilities with dementia
Although some research suggests that dog-assisted therapy may be beneficial for people with dementia living in residential aged care facilities, the intervention has not been adequately investigated. To address this shortcoming, we conducted a randomized controlled trial of dog-assisted therapy versus a human-therapist-only intervention for this population. Fifty-five residents with mild to moderate dementia living […]
The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: a pilot study
Thompson, J. A.,
Cruickshank, T. M.,
Penailillo, L. E.,
Lee, J. W.,
Newton, R. U.,
Barker, R. A.,
Ziman, M. R.
Background and Purpose: Despite advances in the understanding of Huntington’s disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD.; Methods: Twenty patients with HD were assigned to two […]