This database contains 438 studies, archived under the term: "USA"
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Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials
Manson, JoAnn E.,
Chlebowski, Rowan T.,
Stefanick, Marcia L.,
Aragaki, Aaron K.,
Rossouw, Jacques E.,
Prentice, Ross L.,
Anderson, Garnet,
Howard, Barbara V.,
Thomson, Cynthia A.,
LaCroix, Andrea Z.,
Wactawski-Wende, Jean,
Jackson, Rebecca D.,
Limacher, Marian,
Margolis, Karen L.,
Wassertheil-Smoller, Sylvia,
Beresford, Shirley A.,
Cauley, Jane A.,
Eaton, Charles B.,
Gass, Margery,
Hsia, Judith,
Johnson, Karen C.,
Kooperberg, Charles,
Kuller, Lewis H.,
Lewis, Cora E.,
Liu, Simin,
Martin, Lisa W.,
Ockene, Judith K.,
O’Sullivan, Mary Jo,
Powell, Lynda H.,
Simon, Michael S.,
Van Horn, Linda,
Vitolins, Mara Z.,
Wallace, Robert B.
Importance: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.; Objective: To report a comprehensive, integrated overview of findings from the 2 Women’s Health Initiative (WHI) hormone therapy trials with extended postintervention follow-up.; Design, Setting, and Participants: A total of 27,347 postmenopausal women aged 50 […]
Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment
Background: Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates the use of a comprehensive neuropsychological examination to make a differential diagnosis. However, the ability to identify cognitive symptoms that are predictive of aMCI through informant-based […]
Slowing progression of early stages of AD with alternative therapies: a feasibility study
This pilot study identified the feasibility and efficacy of the effect of combining healing touch (HT) and body talk cortices (BTC) on the progression of Alzheimer’s disease (AD). Both HT and BTC elicit the relaxation response and support cognitive function from two different perspectives. A two-group, repeated measures design was used. Subjects (n = 22), 65 or […]
Making physical activity accessible to older adults with memory loss: a feasibility study
Purpose: For individuals with mild cognitive impairment (MCI), memory loss may prevent successful engagement in exercise, a key factor in preventing additional disability. The Resources and Activities for Life Long Independence (RALLI) program uses behavioral principles to make exercise more accessible for these individuals. Exercises are broken into small steps, sequenced, and linked with cues […]
Optimal blood pressure for cognitive function: findings from an elderly African-American cohort study
Liu, Hai,
Gao, Sujuan,
Hall, Kathleen S.,
Unverzagt, Frederick W.,
Lane, Kathleen A.,
Callahan, Christopher M.,
Hendrie, Hugh C.
Objectives: To report the results from a prospective cohort study on the association between blood pressure (BP) and cognitive function in elderly African Americans.; Design: Prospective cohort study conducted from 1997 to 2009.; Setting: Community-based study in Indianapolis.; Participants: African Americans aged 65 years or older (N = 3,145).; Measurements: At each assessment, participant cognitive […]
Deep learning based imaging data completion for improved brain disease diagnosis
Li, Rongjian,
Zhang, Wenlu,
Suk, Heung-Il,
Wang, Li,
Li, Jiang,
Shen, Dinggang,
Ji, Shuiwang
Combining multi-modality brain data for disease diagnosis commonly leads to improved performance. A challenge in using multimodality data is that the data are commonly incomplete; namely, some modality might be missing for some subjects. In this work, we proposed a deep learning based framework for estimating multi-modality imaging data. Our method takes the form of […]
The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease
Lewis, John E.,
McDaniel, H. Reginald,
Agronin, Marc E.,
Loewenstein, David A.,
Riveros, Jorge,
Mestre, Rafael,
Martinez, Mairelys,
Colina, Niurka,
Abreu, Dahlia,
Konefal, Janet,
Woolger, Judi M.,
Ali, Karriem H.
Alzheimer’s disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive […]
Memantine is associated with longer survival than donepezil in a Veterans Affairs prescription database, 1997 to 2008
Lazzeroni, Laura C.,
Halbauer, Joshua D.,
Ashford, J. Wesson,
Noda, Art,
Hernandez, Beatriz,
Azor, Virgina,
Hozack, Nikki,
Hasson, Noelle,
Henderson, Victor W.,
Yesavage, Jerome A.,
Tinklenberg, Jared R.
Alzheimer’s disease (AD) shortens life-expectancy, but the effects of pharmacological treatments for this disorder on mortality have not been studied. We compared two commonly prescribed medications, donepezil and memantine, with respect to the length of survival of veterans presumed to have AD. The Computerized Medical Records System at the Veterans Affairs Palo Alto Health Care […]
A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity
Lavretsky, H.,
Epel, E.S.,
Siddarth, P.,
Nazarian, N.,
Cyr, N. St.,
Khalsa, D.S.,
Lin, J.,
Blackburn, E.,
Irwin, M.R.
Background: This study examined the effects of brief daily yogic meditation on mental health, cognitive functioning, and immune cell telomerase activity in family dementia caregivers with mild depressive symptoms.; Methods: Thirty-nine family dementia caregivers (mean age 60.3 years old (SD = 10.2)) were randomized to practicing Kirtan Kriya or listening to relaxation music for 12 […]