Faxén Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Brismar, Kerstin, Hjorth, Erik, Palmblad, Jan, Vessby, Bengt, Vedin, Inger, Wahlund, Lars-Olof, Cederholm, Tommy

Objectives: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer’s disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).; Design: Randomized, double-blind, placebo-controlled trial.; Setting: Specialist memory clinics in the Stockholm catchment area.; Participants: Two hundred four patients (aged […]

Freund-Levi, Yvonne, Jedenius, Erik, Tysen-Bäckström, Ann Christine, Lärksäter, Marie, Wahlund, Lars-Olof, Eriksdotter, Maria

Objective: To examine the effects of galantamine and risperidone on neuropsychiatric symptoms in dementia (NPSD) and global function.; Methods: Using a randomized, controlled and open-blind, one-center trial at an in- and outpatient clinic at a university hospital, we studied 100 adults with probable dementia and NPSD. Participants received galantamine (N = 50, target dose 24 mg) […]

Faxén-Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Hjorth, Erik, Palmblad, Jan, Vedin, Inger, Cederholm, Tommy, Wahlund, Lars-Olof

Transthyretin (TTR) binds amyloid-β (Aβ) and may reduce brain Aβ, a pathological feature in Alzheimer’s disease (AD). N – 3 fatty acids (FA), docosahexaenoic (DHA), and eicosapentaenoic acid (EPA) may increase TTR transcription in rat hippocampus. We studied effects of n – 3 FA supplementation on TTR-levels in patients with AD. Outpatients were randomized to […]

Érsek, K., Kovács, T., Wimo, A., Kárpati, K., Brodszky, V., Péntek, M., Jönsson, L., Gustavsson, A., McDaid, D., Kenigsberg, P. A., Valtonen, H., Gulácsi, L.

Objective: The main aim of this paper is to give an overview on the quality of life, health care utilisation and costs of dementia in Hungary.; Method: A cross-sectional non-population based study of 88 consecutive dementia patients and their caregivers was conducted in three GP practices and one outpatient setting in 2008. Resource Utilization in […]

Darreh-Shori, Taher, Hosseini, Sharokh Makvand, Nordberg, Agneta

Despite three decades of intensive research in the field of Alzheimer’s disease (AD) and numerous clinical trials of new therapeutic agents, cholinesterase inhibitors (ChEIs) are still the mainstay of therapeutics for AD and dementia with Lewy bodies. Pharmacodynamic analyses of ChEIs provide paradoxical observations. Treatment with the rapidly reversible, noncarbamylating ChEIs (donepezil, galantamine, and tacrine) […]

Conradsson, Mia, Littbrand, Håkan, Lindelöf, Nina, Gustafson, Yngve, Rosendahl, Erik

Objectives: To evaluate the effects of a high-intensity functional exercise programme on depressive symptoms and psychological well-being among older people dependent in activities of daily living (ADL) and living in residential care facilities.; Method: Cluster-randomized controlled study. Participants were 191 older people, aged 65-100, dependent in ADL and with Mini Mental State Examination scores between […]