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Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on MRI: the evaluation of vascular care in Alzheimer’s disease (EVA) study

Authors

Richard, E., Gouw, A. A., Scheltens, P., van Gool, W. A.

Journal

Stroke; A Journal Of Cerebral Circulation, Volume: 41, No.: 3, Pages.: 554-556

Year of Publication

2010

Abstract

Background and Purpose: White matter lesions (WMLs) and cerebral infarcts are common findings in Alzheimer disease and may contribute to dementia severity. WMLs and lacunar infarcts may provide a potential target for intervention strategies. This study assessed whether multicomponent vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs and prevents occurrence of new infarcts.; Methods: A randomized controlled clinical trial, including 123 subjects, compared vascular care with standard care in patients with Alzheimer disease with cerebrovascular lesions on MRI. Progression of WMLs, lacunes, medial temporal lobe atrophy, and global cortical atrophy were semiquantitatively scored after 2-year follow-up.; Results: Sixty-five subjects (36 vascular care, 29 standard care) had a baseline and a follow-up MRI and in 58 subjects, a follow-up scan could not be obtained due to advanced dementia or death. Subjects in the vascular care group had less progression of WMLs as measured with the WML change score (1.4 versus 2.3, P=0.03). There was no difference in the number of new lacunes or change in global cortical atrophy or medial temporal lobe atrophy between the 2 groups.; Conclusions: Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs. Treatment aimed at vascular risk factors in patients with early Alzheimer disease may be beneficial, possibly in an even earlier stage of the disease.;

Bibtex Citation

@article{Richard_2010, doi = {10.1161/strokeaha.109.571281}, url = {http://dx.doi.org/10.1161/strokeaha.109.571281}, year = 2010, month = {jan}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {41}, number = {3}, pages = {554--556}, author = {E. Richard and A. A. Gouw and P. Scheltens and W. A. van Gool}, title = {Vascular Care in Patients With Alzheimer Disease With Cerebrovascular Lesions Slows Progression of White Matter Lesions on {MRI}: The Evaluation of Vascular Care in Alzheimer{textquotesingle}s Disease ({EVA}) Study}, journal = {Stroke} }

Keywords

advice, aged, aged, 80 and over, alzheimer disease, and, cerebrovascular disorders, cessation, dietary, disease progression, health behavior, humans, loss, magnetic resonance imaging, nerve fibers myelinated, pathology, risk factors, therapy, weight

Countries of Study

Netherlands

Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

Risk reduction (of dementia and co-morbidities)

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Exercise (inc. dancing), Other