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Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer’s disease


Gillette-Guyonnet, Sophie, Andrieu, Sandrine, Dantoine, Thierry, Dartigues, Jean-François, Touchon, Jacques, Vellas, B.


Alzheimer's & Dementia: The Journal Of The Alzheimer's Association, Volume: 5, No.: 2, Pages.: 114-121

Year of Publication



Background: Because no effective curative approaches are available, preventive approaches in the field of Alzheimer’s disease (AD) are needed. We present the design of the ongoing Multidomain Alzheimer Preventive Trial (MAPT) Study. Several previous studies suggested that many factors may be involved in the occurrence of AD at late ages. Because of the probable multifactorial nature of AD, it seems logical to initiate multidomain interventions to examine their potential synergistic effects. The MAPT Study aims to evaluate the efficacy of a multidomain intervention (nutritional, physical, and cognitive training) and omega 3 treatment in the prevention of cognitive decline in frail elderly persons aged 70 years or over. The study also collects imaging and biological data that could be used in future AD prevention and treatment trials.; Methods: The MAPT Study is a 3-year, randomized, controlled trial conducted by university hospital practitioners specializing in memory disorders in four French cities (Bordeaux, Limoges, Montpellier, and Toulouse). The study plans to enroll 1200 frail elderly subjects on the basis of at least one of the following criteria: subjective memory complaint spontaneously expressed to a general practitioner, limitation in one instrumental activity of daily living (IADL), and slow walking speed. To demonstrate the protective effect of interventions, subjects are randomized into one of the following four groups: omega 3 alone, multidomain intervention alone, omega 3 plus multidomain intervention, or placebo (n = 300 each). The principal outcome measure is a change in cognitive function at 3 years, as determined by the Grober and Buschke Test.; Conclusions: The MAPT Study is the first preventive trial involving multidomain interventions. Final results should be available in 2013.;

Bibtex Citation

@article{Gillette_Guyonnet_2009, doi = {10.1016/j.jalz.2009.01.008}, url = {}, year = 2009, month = {mar}, publisher = {Elsevier {BV}}, volume = {5}, number = {2}, pages = {114--121}, author = {Sophie Gillette-Guyonnet and Sandrine Andrieu and Thierry Dantoine and Jean-Fran{c{c}}ois Dartigues and Jacques Touchon and B. Vellas}, title = {Commentary on {textquotedblleft}A roadmap for the prevention of dementia {II}. Leon Thal Symposium 2008.{textquotedblright} The Multidomain Alzheimer Preventive Trial ({MAPT}): A new approach to the prevention of Alzheimer{textquotesingle}s disease}, journal = {Alzheimer{textquotesingle}s {&} Dementia} }


3, administration & dosage, alzheimer disease, biological markers, brain, cognition disorders, cognitive therapy, data collection, diet therapy, disease progression, drug effects, drug therapy, exercise therapy, humans, metabolism, methods, neuropsychological tests, nutritional, omega, outcome assessment (health care), patient selection, physiopathology, prevention & control, research design, sample size, training

Countries of Study


Types of Study

Randomised Controlled Trial

Type of Outcomes




Type of Interventions

Non-pharmacological Treatment, Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention, Exercise (inc. dancing), Other