Laxton, Adrian W., Tang-Wai, David F., McAndrews, Mary Pat, Zumsteg, Dominik, Wennberg, Richard, Keren, Ron, Wherrett, John, Naglie, Gary, Hamani, Clement, Smith, Gwenn S., Lozano, Andres M.

Objective: Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits.; Methods: We conducted a phase I trial in 6 patients with mild AD receiving […]

Sjöbeck, Martin, Elfgren, Christina, Larsson, Elna-Marie, Brockstedt, Sara, Lätt, Jimmy, Englund, Elisabet, Passant, Ulla

White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated […]

Freedman, Morris, Binns, Malcolm A., Black, Sandra E., Levine, Brian, Miller, Bruce L., Ramirez, Joel, Szilagyi, Gregory M., Scott, Christopher J. M., McNeely, Alicia A., Stuss, Donald T.

We studied behavioral variant frontotemporal dementia (bvFTD) using object alternation (OA) as a novel probe of cognition. This task was adopted from animal models and is sensitive to ventrolateral-orbitofrontal and medial frontal function in humans. OA was administered to bvFTD patients, normal controls, and a dementia control group with Alzheimer disease (AD). Two other frontal […]