Wroolie, Tonita E., Kenna, Heather A., Williams, Katherine E., Powers, Bevin N., Holcomb, Megan, Khaylis, Anna, Rasgon, Natalie L.

Objective: Much controversy exists and many questions remain unanswered about the effects of hormone therapy (HT) on cognition in postmenopausal women. There is growing evidence suggesting that HT compounds containing conjugated equine estrogen (CEE) have negative effects on cognition whereas 17β-estradiol (17β-E) either has positive or neutral effects. The present study sought to further examine […]

Ryan, Joanne, Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra, Kildea, Daniel, Henderson, Victor W.

Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women’s Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, […]

Silverman, Daniel H. S., Geist, Cheri L., Kenna, Heather A., Williams, Katherine, Wroolie, Tonita, Powers, Bevin, Brooks, John, Rasgon, Natalie L.

Differential cerebral metabolic effects of various hormone therapy formulations, and their associations with cognitive status, remain to be established. The principal aim of the current study was to assess relationships between regional cerebral metabolism and estrogen-based hormone therapies. Postmenopausal women (n=53) at elevated risk for Alzheimer’s disease (AD) were on estrogen-containing hormone therapy for at […]

Yamada, Shizuru, Akishita, Masahiro, Fukai, Shiho, Ogawa, Sumito, Yamaguchi, Kiyoshi, Matsuyama, Jun, Kozaki, Koichi, Toba, Kenji, Ouchi, Yasuyoshi

Aim: There is little evidence that dehydroepiandrosterone (DHEA) has beneficial effects on physical and psychological functions in older women. We investigated the effect of DHEA supplementation on cognitive function and ADL in older women with cognitive impairment.; Methods: A total of 27 women aged 65-90 years (mean ± standard deviation, 83 ± 6) with mild […]

Valen-Sendstad, Arnhild, Engedal, Knut, Stray-Pedersen, Babill, Strobel, Carsten, Barnett, Liv, Meyer, Nicolay, Nurminemi, Minna

Objective: To elucidate the effects of low-dose 17beta-estradiol and norethisterone (hormone therapy [HT]) versus placebo in women with Alzheimer Disease (AD) on cognition, depressive symptoms, and activities of daily living.; Design: A 12-month randomized, double-blind, placebo-controlled study, stratified by apolipoprotein E (ApoE) genotype (with versus without the epsilon4 allele), duration of education (< or =9 […]

Tierney, Mary C., Oh, Paul, Moineddin, Rahim, Greenblatt, Ellen M., Snow, W. Gary, Fisher, Rory H., Iazzetta, John, Hyslop, Peter St George, MacLusky, Neil J.

We examined whether estradiol and norethindrone hormone therapy (HT) prevented decline in delayed verbal recall in older women with normal to mildly impaired memory functioning. This was a 2-year, randomized, double-blind, placebo-controlled trial of 142 women aged 61-87, randomly assigned to receive 1 mg 17-beta estradiol daily and 0.35 mg norethindrone 3 days/week or daily […]

Sherwin, Barbara B., Chertkow, Howard, Schipper, Hyman, Nasreddine, Ziad

This randomized, placebo-controlled, cross-over study investigated whether estrogen treatment would have a beneficial effect on tests of verbal memory in men with mild cognitive impairment (MCI). Forty-three men newly diagnosed with MCI were administered a battery of neuropsychological tests before randomly receiving 12 weeks of treatment with estrogen or placebo followed by a 12 week […]