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This database contains 664 studies, archived under the term: "Randomised Controlled Trial"

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Mindfulness-based stress reduction for family caregivers: a randomized controlled trial

Purpose: Caring for a family member with dementia is associated with chronic stress, which can have significant deleterious effects on caregivers. The purpose of the Balance Study was to compare a mindfulness-based stress reduction (MBSR) intervention to a community caregiver education and support (CCES) intervention for family caregivers of people with dementia.; Design and Methods: […]

A feasibility study and pilot randomised trial of a tailored prevention program to reduce falls in older people with mild dementia

Background: People with dementia have a disproportionately high rate of falls and fractures and poorer outcomes, yet there is currently no evidence to guide falls prevention in this population.; Methods: A randomised trial design was used to test feasibility of study components and acceptability of a home hazard reduction and balance and strength exercise fall […]

Providing activity for people with dementia in care homes: a cluster randomised controlled trial

Background: Activity levels remain low in care homes, but activity engagement can enhance residents’ quality of life.; Aim: This study aimed to assess an occupational therapy programme designed to enable care home staff to increase activity provision.; Method: A cluster randomised controlled trial with blinded assessment of outcome was conducted. A total of 210 residents […]

Randomised controlled trial of a family‐led mutual support programme for people with dementia

This controlled trial was to investigate the effectiveness of a family-led mutual support group program for Chinese people with dementia on caregivers’ quality of life, burden and social support and clients’ mental state and institutionalization. The participants in this study were family members caring for a relative with dementia at home and they were recruited […]

Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study

Background: Compared with younger people, the elderly are more likely to suffer from overactive bladder (OAB) and to have other chronic conditions that affect physical or cognitive function. Despite this, there are few data on the cognitive safety of antimuscarinic agents in older patients and none that examine the effect of these agents on those […]

Practice example: neurodegenerative disorders: randomised controlled multicentre trial of home-based occupational therapy for patients with dementia

This paper summarises the methods and results of a seven-centre, single-blind, parallel group, actively controlled randomised trial evaluating the effectiveness of a Dutch 10-session community occupational therapy programme for patients with mild to moderate Alzheimer’s disease in German routine healthcare. Methodological aspects for future research on complex psychosocial interventions are discussed. (As supplied by publisher). […]

The effect of music therapy compared with general recreational activities in reducing agitation in people with dementia: a randomised controlled trial

Objective: This study aimed to compare the effects of music therapy with general recreational day activities in reducing agitation in people with dementia, residing in nursing home facilities.; Methods: In a randomised controlled design, residents with dementia (n = 94) were allocated to either music therapy or recreational activities. Both music therapy and general activities were offered […]

Memantine in behavioral variant frontotemporal dementia: negative results

We tested the efficacy and tolerability of one-year treatment with memantine (10 mg bid) in behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years, with a Mini-Mental Status Examination (MMSE) score ≥19, were enrolled in a national, randomized, double-blind, placebo-controlled (DBPC), Phase II trial. The primary endpoint was the CIBIC-Plus (Clinician’s Interview-Based […]

Six-month walking program changes cognitive and ADL performance in patients with Alzheimer

Motor inactivity is typical in the later stages of Alzheimer’s disease although there is evidence that physical exercise can reduce depression and enhance performance of daily activities. The aim of this study was to determine whether a walking program could reduce the functional and cognitive decline of elderly nursing home residents in the later stages […]

EHT0202 in Alzheimer’s disease: a 3-month, randomized, placebo-controlled, double-blind study

Background: EHT0202 (etazolate hydrochloride) is a new compound exhibiting both potential disease-modifying and symptomatic treatment properties in Alzheimer’s Disease increasing alpha-secretase activity and sAPP alpha secretion, as well as acting as a GABA-A receptor modulator and as a PDE-4 inhibitor.; Methods: This pilot, randomized, double-blind, placebo-controlled, parallel group, multicentre, Phase IIA study was conducted in […]

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