This database contains 244 studies, archived under the term: "Cohort Study"
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High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
Baker, Laura D.,
Bayer-Carter, Jennifer L.,
Skinner, Jeannine,
Montine, Thomas J.,
Cholerton, Brenna A.,
Callaghan, Maureen,
Leverenz, James B.,
Walter, Brooke K.,
Tsai, Elaine,
Postupna, Nadia,
Lampe, Johanna,
Craft, Suzanne
We previously showed that amyloid-β 1-42 (Aβ(42)) levels in cerebrospinal fluid (CSF) were markedly altered in response to a 4-week dietary intervention in normal aging and mild cognitive impairment (MCI). Here, we re-examined the data to assess whether diet-induced effects on CSF Aβ(42) were modulated by high intensity physical activity (hi-PA). Normal older adults (n […]
Physical therapy in Huntington’s disease–toward objective assessments?
Bohlen, S.,
Ekwall, C.,
Hellström, K.,
Vesterlin, H.,
Björnefur, M.,
Wiklund, L.,
Reilmann, R.
Background and Purpose: Physical therapy is recommended for the treatment of Huntington’s disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy […]
Subgroup analysis of US and non-US patients in a global study of high-dose donepezil (23 mg) in moderate and severe Alzheimer’s disease
Salloway, Stephen,
Mintzer, Jacobo,
Cummings, Jeffrey L.,
Geldmacher, David,
Sun, Yijun,
Yardley, Jane,
Mackell, Joan
To better understand responses in the large number of US-based patients included in a global trial of donepezil 23 mg/d versus 10 mg/d for moderate-to-severe Alzheimer’s disease (AD), post hoc exploratory analyses were performed to assess the efficacy and safety in US and non-US (rest of the world [RoW]) patient subgroups. In both subgroups, donepezil […]
Pain and distress in advanced dementia: choosing the right tools for the job
Objective: There is a concern that pain is under-recognized in dementia. However, there may be other causes of distress. We wished to evaluate the utility of a distress tool and a pain tool.; Methods: Nursing home residents with advanced dementia were observed using pain (Pain Assessment in Advanced Dementia scale (PAINAD)) and distress (Disability Distress […]
Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial
Ballard, Clive,
Jones, Emma,
Gauge, Nathan,
Aarsland, Dag,
Nilsen, Odd Bjarte,
Saxby, Brian K.,
Lowery, David,
Corbett, Anne,
Wesnes, Keith,
Katsaiti, Eirini,
Arden, James,
Amoako, Derek,
Prophet, Nicholas,
Purushothaman, Balaji,
Green, David
Background: The study determined the one year incidence of post operative cognitive decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic intervention in reducing post-operative cognitive impairment in older adults (over 60 years of age) undergoing elective orthopaedic or abdominal surgery.; Methods and Trial Design: The design was a prospective cohort study with a […]
Is gardening a stimulating activity for people with advanced Huntington’s disease?
This study evaluated adapted gardening as an activity for people with advanced Huntington’s disease (HD) and explored its therapeutic aspects. Visitors and staff completed a questionnaire and participated in structured interviews to capture further information, whereas a pictorial questionnaire was designed for residents with communication difficulties. Staff reported that gardening was a constructive, outdoor activity […]
A comparison of performance-based measures of function in HIV-associated neurocognitive disorders
Gandhi, Nishiena S.,
Skolasky, Richard L.,
Peters, Katherine B.,
Moxley, Richard T. th,
Creighton, Jason,
Roosa, Heidi Vornbrock,
Selnes, Ola A.,
McArthur, Justin,
Sacktor, Ned
The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test […]
Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe
Eisele, Marion,
Zimmermann, Thomas,
Köhler, Mirjam,
Wiese, Birgitt,
Heser, Kathrin,
Tebarth, Franziska,
Weeg, Dagmar,
Olbrich, Julia,
Pentzek, Michael,
Fuchs, Angela,
Weyerer, Siegfried,
Werle, Jochen,
Leicht, Hanna,
König, Hans-Helmut,
Luppa, Melanie,
Riedel-Heller, Steffi,
Maier, Wolfgang,
Scherer, Martin
Background: Social support has been suggested to positively influence cognition and mortality in old age. However, this suggestion has been questioned due to inconsistent operationalisations of social support among studies and the small number of longitudinal studies available. This study aims to investigate the influence of perceived social support, understood as the emotional component of […]
The NIH stroke scale can establish cognitive function after stroke
Background: Cognitive impairment is an important but underrecognised consequence of stroke. We investigated whether a subset of items from the NIH Stroke Scale (NIHSS) could yield valid information on cognitive status in a group of stroke patients.; Methods: 149 stroke patients from the Göteborg 70+ Stroke Study were investigated after 18 months. We extracted 4 […]