This database contains 162 studies, archived under the term: "Before and After Study"
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Diagnosis of Alzheimer’s disease patients with rapid cognitive decline in clinical practice: interest of the Deco questionnaire
Carcaillon, L.,
Berrut, G.,
Sellal, F.,
Dartigues, J. F.,
Gillette, S.,
Pere, J. J.,
Bourdeix, I.
Background: Patients with Alzheimer’s disease (AD) who deteriorate rapidly are likely to have a poorer prognosis. There is a clear need for a clinical assessment tool to detect such a decline in newly diagnosed patients.; Objective: To identify the predictive factors of rapid cognitive decline (RCD) in a cohort of patients with mild to moderate […]
Group therapy for patients with mild cognitive impairment and their significant others: Results of a waiting-list controlled trial
Banningh, Liesbeth W. A. Joosten-Weyn,
Prins, Judith B.,
Vernooij-Dassen, Myrra J. F. J.,
Wijnen, Hugo H.,
Rikkert, Marcel G. M. Olde,
Kessels, Roy P. C.
Background: Patients with mild cognitive impairment (MCI) have to deal with an uncertain prognosis and also face a multitude of memory-related problems and psychosocial consequences. A newly developed group programme proved to be feasible, however, it needed confirmation by a controlled study. Aim: This controlled study evaluates this group therapy for MCI patients aimed to […]
Clinical outcomes and complications of enteral nutrition among older adults
Attanasio, A.,
Bedin, M.,
Stocco, S.,
Negrin, V.,
Biancon, A.,
Cecchetto, G.,
Tagliapietra, M.
Aim: Several reviews or clinical trials published in the last years have not demonstrated that tube feeding can improve outcomes, including inhalation pneumonia, survival, pressure sores. Further, high rate of risks are recognized. Therefore, this practice should be discouraged for severely demented patients. The aim of this study was to assess the validity of these […]
Measuring memory in large group settings using a continuous recognition test
Memory function generally deteriorates with age, and memory impairments are a common symptom of serious illness such as dementia. Although screening tests are widely used throughout Medicine, they are not yet commonly used to detect memory impairments. The objective of this study was to characterize an audience-based memory test suitable for administration to a large […]
What predicts cognitive decline in de novo Parkinson’s disease?
Arnaldi, Dario,
Campus, Claudio,
Ferrara, Michela,
Famà, Francesco,
Picco, Agnese,
De Carli, Fabrizio,
Accardo, Jennifer,
Brugnolo, Andrea,
Sambuceti, Gianmario,
Morbelli, Silvia,
Nobili, Flavio
Subtle cognitive impairment can be detected in early Parkinson’s disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess which clinical, neuropsychological, and functional neuroimaging (dopamine transporter [DAT] and perfusion single photon emission computed tomography [SPECT]) characteristics at baseline was predictive of cognitive decline during an […]
Supervised exercise to reduce agitation in severely cognitively impaired persons
Background: Several studies have shown an improvement in depression, activities of daily living, and agitation in cognitively impaired subjects who undergo a long-term exercise program. These studies have not considered the short-term effects of exercise.; Objectives: The purpose of this study was to investigate the short-term effects of a limited, supervised exercise program on agitation, […]