This database contains 530 studies, archived under the term: "Dementia (general / unspecified)"
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Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia
Tay, Laura,
Chua, Kia Chong,
Chan, Mark,
Lim, Wee Shiong,
Ang, Yue Ying,
Koh, Evonne,
Chong, Mei Sian
Background: Discordance between patient- and caregiver-reported quality of life (QoL) is well recognized. This study sought to (i) identify predictors of discrepancy between patient- and caregiver-rated QoL amongst community-dwelling persons with mild-to-moderate dementia, and (ii) differentiate between patients who systematically rate their QoL lower versus those who rate their QoL higher relative to their caregiver […]
Infection hospitalization increases risk of dementia in the elderly
Tate, Judith A.,
Snitz, Beth E.,
Alvarez, Karina A.,
Nahin, Richard L.,
Weissfeld, Lisa A.,
Lopez, Oscar,
Angus, Derek C.,
Shah, Faraaz,
Ives, Diane G.,
Fitzpatrick, Annette L.,
Williamson, Jeffrey D.,
Arnold, Alice M.,
DeKosky, Steven T.,
Yende, Sachin
Objectives: Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults.; Design: Secondary analysis of a randomized multicenter […]
Physical and psychological effects of 6-week tactile massage on elderly patients with severe dementia
Suzuki, M.,
Tatsumi, A.,
Otsuka, T.,
Kikuchi, K.,
Mizuta, A.,
Makino, K.,
Kimoto, A.,
Fujiwara, K.,
Abe, T.,
Nakagomi, T.,
Hayashi, T.,
Saruhara, T.
Tactile massage is a soft massage that improves physical relaxation and psychological well-being. The purpose of this study was to clarify the effects of a 6-week tactile massage on changes in physical and mental function, symptoms of behavioral and psychological symptoms of dementia (BPSD) among elderly patients with dementia. In addition, chromogranin A (CgA) levels […]
Yokukansan treatment of chronic renal failure patients receiving hemodialysis, with behavioral and psychological symptoms of dementia: an open-label study
Sumiyoshi, Hidenori,
Mantani, Akio,
Nishiyama, Satoshi,
Fujiwaki, Soh,
Ohta, Shoichiro,
Masuda, Yoshikazu,
Tomita, Youhei,
Tarumoto, Naofumi,
Yamawaki, Shigeto
Objective: The efficacy and safety of yokukansan (YKS) for chronic renal failure (CRF) patients receiving hemodialysis with behavioral and psychological symptoms of dementia (BPSD) was evaluated.; Methods: Twelve CRF patients receiving hemodialysis with BPSD were recruited and 7.5 g of YKS powder was added to ongoing therapy with antipsychotics. Neuropsychiatric Inventory (NPI) criteria and Barthel […]
Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial
Sullivan, Mark D.,
Katon, Wayne J.,
Lovato, Laura C.,
Miller, Michael E.,
Murray, Anne M.,
Horowitz, Karen R.,
Bryan, R. Nick,
Gerstein, Hertzel C.,
Marcovina, Santica,
Akpunonu, Basil E.,
Johnson, Janice,
Yale, Jean Francois,
Williamson, Jeff,
Launer, Lenore J.
Importance: Depression has been identified as a risk factor for dementia among patients with type 2 diabetes mellitus but the cognitive domains and patient groups most affected have not been identified.; Objective: To determine whether comorbid depression in patients with type 2 diabetes accelerates cognitive decline.; Design: A 40-month cohort study of participants in the […]
ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients
Steinacker, Petra,
Klafki, Hans,
Lehnert, Stefan,
Jesse, Sarah,
Arnim, Christine A. F. V.,
Tumani, Hayrettin,
Pabst, Alice,
Kretzschmar, Hans A.,
Wiltfang, Jens,
Otto, Markus
The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be supported by several biochemical markers in cerebrospinal fluid (CSF) such as 14-3-3 proteins and tau protein. Unfortunately, none of the currently known markers are suited for screening or seems to be directly related to the pathophysiological process. A marker fulfilling these criteria might facilitate the early […]
The Peaceful Mind program: A pilot test of a cognitive–behavioral therapy–based intervention for anxious patients with Dementia
Stanley, Melinda A.,
Calleo, Jessica,
Bush, Amber L.,
Wilson, Nancy,
Snow, A. Lynn,
Kraus-Schuman, Cynthia,
Paukert, Amber L.,
Petersen, Nancy J.,
Brenes, Gretchen A.,
Schulz, Paul E.,
Williams, Susan P.,
Kunik, Mark E.
Objectives: To assess feasibility and to conduct a preliminary evaluation of outcomes following Peaceful Mind, a cognitive-behavioral therapy-based intervention for anxiety in dementia, relative to usual care. Design: Pilot randomized controlled trial including assessments at baseline and 3 and 6 months. Setting: Houston, TX. Participants: Thirty-two outpatients diagnosed with mild (47%) or moderate (53%) dementia […]