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Rivastigmine transdermal patch and physical exercises for Alzheimer’s disease: A randomized clinical trial


Aguiar, Paula, Monteiro, Larissa, Feres, Ana, Gomes, Irenio, Melo, Ailton


Current Alzheimer Research, Volume: 11, No.: 6, Pages.: 532-537

Year of Publication



Objective: To determine the effects of rivastigmine patch associated with physical exercise versus rivastigmine patch alone in quality of life (QOL), cognition, activities of daily living (ADL) and functional mobility in Alzheimer’s disease (AD)subjects. Methods: A randomized, controlled, single-blinded trial was conducted in 40 patients with mild to moderate stages of AD. All patients were daily treated with rivastigmine transdermal patch at a stable dose of 4.6 mg and randomized into two groups: physical exercises or control. The exercise program consisted of aerobic, flexibility, strength and balance movements, twice a week for 6 months. Main outcomes were Quality of Life in Alzheimer’s disease scale (QOL), Activities of Daily Living Questionnaire (ADL), Mini-Mental State Examination (MMSE) and “Time Up and Go Test”. Results: Thirty-four patients completed the study. After 6 months, there was a significant improvement in QOL of patients randomized to physical exercise group (P < 0.05). In both groups, there was an improvement on caregivers QOL (P > 0.05). When considering cognitive functions, there was no difference between groups. The ability to perform ADL worsened in the group enrolled to RTP alone. There was an improvement in functional mobility in the group treated with RTP. Conclusion: Our results suggest that the association between physical exercises and RTP improves QOL in patients with AD. Cognition remained unchanged in both groups. Regarding the effect of physical exercises in ADL, further trials are necessary to confirm these results. (PsycINFO Database Record (c) 2014 APA, all rights reserved). (journal abstract)

Bibtex Citation

@article{Aguiar_2014, doi = {10.2174/1567205011666140618102224}, url = {}, year = 2014, month = {jul}, publisher = {Bentham Science Publishers Ltd.}, volume = {11}, number = {6}, pages = {532--537}, author = {Paula Aguiar and Larissa Monteiro and Ana Feres and Irenio Gomes and Ailton Melo}, title = {Rivastigmine Transdermal Patch and Physical Exercises for Alzheimer's Disease: A Randomized Clinical Trial}, journal = {{CAR}} }


activities of daily living, alzheimer’s disease, cholinesterase inhibitors, clinical trials, dementia, drug administration methods, drug therapy, exercise, interdisciplinary treatment approach, patch, quality of life, rivastigmine

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

ADLs/IADLs, Cognition, Quality of Life of Carer, Quality of Life of Person With Dementia

Type of Interventions

Non-pharmacological Treatment, Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime

Non-Pharmaceutical Interventions

Exercise (inc. dancing)