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Prevalence of anosognosia in Alzheimer’s disease


Turró-Garriga, Oriol, Conde-Sala, Josep Lluís, Reñé-Ramírez, Ramón, López-Pousa, Secundino, Gascón-Bayarri, Jordi, Garre-Olmo, Josep


Medicina Clínica, Volume: 143, No.: 1, Pages.: 13-19

Year of Publication



Background and Objective: Anosognosia is a disorder that affects the clinical presentation of Alzheimer’s disease (AD), increasing in frequency with the evolution of AD. The objective was to determine the prevalence of anosognosia and analyze the associated factors and predictors.; Patients and Method: Multicenter transversal and observational study of 345 AD patients. Anosognosia was assessed by Anosognosia Questionnaire-Dementia and the evolutionary stage with the Global Deterioration Scale (GDS). Tests used were Mini-Mental State Examination, Disability Assessment for Dementia and Neuropsychiatric Inventory to assess cognition, functional status and neuropsychiatric symptoms, respectively. We adjusted linear regression models to determine the associated variables and binary logistic regression (RLog) to identify predictors of anosognosia.; Results: The overall prevalence of anosognosia was 46.7% (95% confidence interval [95% CI] 41.3 to 52.1). The prevalence in stages was 28.4% (GDS 4), 64.6% (GDS 5) and 91.4% (GDS 6). The RLog identified as predictors older age (odds ratio [OR] 1.04; 95% CI 1.01-1.09), lower functional capacity (OR 0.96; 95% CI 0.93-0.98), lower cognitive level (OR 0.9; 95% CI 0.88-0.99), and greater apathy (OR 1.1; 95% CI 1.03-1.18), disinhibition (OR 1.2; 95% CI 1.09-1.50), irritability (OR 1.1; 95% CI 1.09-1.50) and motor disorders (OR 1.2; 95% CI 1.09-1.50).; Conclusions: Anosognosia increases with further deterioration. In patients with a mild impairment, predictor variables were apathy, disinhibition and motor disorders.; Copyright © 2013 Elsevier España, S.L. All rights reserved.

Bibtex Citation

@article{Turr_Garriga_2014, doi = {10.1016/j.medcli.2013.04.043}, url = {}, year = 2014, month = {jul}, publisher = {Elsevier {BV}}, volume = {143}, number = {1}, pages = {13--19}, author = {Oriol Turr{'{o}}-Garriga and Josep Llu{'{i}}s Conde-Sala and Ram{'{o}}n Re{~{n}}{'{e}}-Ram{'{i}}rez and Secundino L{'{o}}pez-Pousa and Jordi Gasc{'{o}}n-Bayarri and Josep Garre-Olmo}, title = {Prevalencia de anosognosia en la enfermedad de Alzheimer}, journal = {Medicina Cl{'{i}}nica} }


activities of daily living, age factors, aged, aged, 80 and over, agnosia, alzheimer disease, alzheimer’s disease, anosognosia, apathy, complications, depression, diagnosis, disease progression, enfermedad de alzheimer, epidemiology, estudio multicntrico, etiology, female, for, humans, impulse control disorders, male, multicenter study, neuropsychological tests, prevalence, prevalencia, psychology, questionnaires, self concept, severity of illness index, spain, testing

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Cohort Study

Type of Outcomes


Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)