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Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia

Authors

Sommer, Oskar H., Aga, Olav, Cvancarova, Milada, Olsen, Inge C., Selbaek, Geir, Engedal, Knut

Journal

Dementia And Geriatric Cognitive Disorders, Volume: 27, No.: 2, Pages.: 155-163

Year of Publication

2009

Abstract

Background/aims: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer’s disease, vascular dementia or both.; Methods: This is an 8-week, multicenter, randomized, double-blind, placebo-controlled trial carried out independently of the pharmaceutical industry. Changes in the agitation and aggression subscore of the Neuropsychiatric Inventory (NPI) were the primary outcomes. The secondary out- comes were the changes in the caregivers’ total burden scores (measured by the NPI) and changes in the Brief Agitation Rating Scale (BARS).; Results: In total, 103 institutionalized patients at 35 sites were randomized to the trial. After 8 weeks, no statistically significant differences were found between the 2 groups for all outcomes. A trend was observed in favor of the OXC group in the reduction in the scores on the BARS (p = 0.07).; Conclusion: This study found no significant effect of OXC in treatment of agitation and aggression in patients with dementia.; Copyright 2009 S. Karger AG, Basel.

Bibtex Citation

@article{Sommer_2009, doi = {10.1159/000199236}, url = {http://dx.doi.org/10.1159/000199236}, year = 2009, month = {feb}, publisher = {S. Karger {AG}}, volume = {27}, number = {2}, pages = {155--163}, author = {Oskar H. Sommer and Olav Aga and Milada Cvancarova and Inge C. Olsen and Geir Selbaek and Knut Engedal}, title = {Effect of Oxcarbazepine in the Treatment of Agitation and Aggression in Severe Dementia}, journal = {Dementia and Geriatric Cognitive Disorders} }

Keywords

adverse effects, aged, aged, 80 and over, aggression, alzheimer disease, analogs derivatives, anticonvulsants, carbamazepine, complications, dementia, dementia vascular, double-blind method, drug effects, drug therapy, etiology, female, humans, inpatients, male, middle aged, oxcarbazepine, psychology, psychomotor agitation, therapeutic use, treatment outcome

Countries of Study

Norway

Types of Dementia

Alzheimer’s Disease, Vascular Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

Behaviour, Carer Burden (instruments measuring burden)

Settings

Nursing Homes

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants
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