Authors

Na, Hae-Ri, Kim, SangYun, Choi, Seong Hye, Yang, Dong-Won, Bae, Hee-Joon, Kim, Jung-Eun, Park, Mee-Young, Shim, Yong-Soo, Kim, Byung-Kun, Kwon, Jae-Cheol, Yoo, Bong Goo, Kim, Byeong-Chae, Lee, Jung-Seok

Journal

Geriatrics & Gerontology International, Volume: 11, No.: 1, Pages.: 90-97

Year of Publication

2011

Abstract

Aim: Donepezil has not been evaluated in Korean patients with Alzheimer’s disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL).; Methods: This study was a 48-week open-label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures.; Results: Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy-nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini-Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups.; Conclusion: The presence of CVL should not deter clinicians from treating AD with donepezil.; © 2010 Japan Geriatrics Society.

Bibtex Citation

@article{Na_2010, doi = {10.1111/j.1447-0594.2010.00649.x}, url = {http://dx.doi.org/10.1111/j.1447-0594.2010.00649.x}, year = 2010, month = {sep}, publisher = {Wiley-Blackwell}, volume = {11}, number = {1}, pages = {90--97}, author = {Hae-Ri Na and SangYun Kim and Seong-Hye Choi and Dong-Won Yang and Hee-Joon Bae and Jung-Eun Kim and Mee-Young Park and Yong-Soo Shim and Byung-Kun Kim and Jae-Cheol Kwon and Bong-Goo Yoo and Byeong-Chae Kim and Jung-Seok Lee}, title = {Donepezil treatment in Alzheimer{textquotesingle}s disease patients with and without cerebrovascular lesions: A preliminary report}, journal = {Geriatrics {&} Gerontology International} }